CABLES1

Gene Symbol CABLES1
Entrez Gene 91768
Alt Symbol CABL1, CABLES, HsT2563, IK3-1
Species Human
Gene Type protein-coding
Description Cdk5 and Abl enzyme substrate 1
Other Description CDK5 and ABL1 enzyme substrate 1|interactor with CDK3 1
Swissprots B4DK60 Q8N3Y8 Q8NA22 Q9BTG1 Q8TDN4
Accessions ACA05957 EAX01147 EAX01148 Q8TDN4 AF348525 AAL83906 AK025627 AK093243 BAC04107 AK296407 BAG59072 AK304880 BAG65617 BC004124 AAH04124 BC015686 BC037218 AAH37218 EF028204 ABL77400 NM_001100619 NP_001094089 NM_001256438 NP_001243367 NM_138375 NP_612384 NR_023359
Function Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269|PubMed:11585773, ECO:0000269|PubMed:14729625}.

Cables1 (D-10) - sc-374316 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cables1 (D-10): sc-374316. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Cables1 (M-19) - sc-14794 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CABLES1 antibody - ab75535 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CABLES1 antibody (ab75535) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lane 3 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell Lysate Lane 4 : SK N SH (Human neuroblastoma) Whole Cell Lysate Lane 5 : SK N BE (Human neuroblastoma) Whole Cell Lysate Lane 6 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CABLES1 antibody - ab168197 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CABLES1 antibody (ab168197) at 1 µg/mlLane 1 : CABLES1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-CABLES1 antibody - ab130967 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CABLES1 antibody (ab130967) at 1 µg/ml + RPMI-8226 cell lysate at 10 µgSecondaryGoat anti-Rabbit IgG HRP

Anti-CABLES1 antibody - ab134258 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CABLES1 antibody (ab134258) at 1 µg/ml + Human fetal heart lystae at 10 µgSecondaryGoat anti-Rabbit IgG HRP

Anti-IK3-1 / CABLES1 Antibody - LS-C306687 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IK3-1 / CABLES1 Antibody (aa539-588) - LS-C292090 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IK3-1 / CABLES1 Antibody (aa516-565) - LS-C151815 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IK3-1 / CABLES1 antibody Western Blot of Fetal Heart.

Anti-IK3-1 / CABLES1 Antibody (aa214-263) - LS-C151816 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IK3-1 / CABLES1 antibody Western Blot of RPMI-8226.

Anti-IK3-1 / CABLES1 Antibody (aa561-610) - LS-C119402 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from LOVO cells, using Ik3-1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-IK3-1 / CABLES1 Antibody (Lys588) - LS-C176874 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Cables1 (K588) pAb in extracts from LOVO cells.

CABLES1 Antibody - NB100-92443 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CABLES1 Antibody [NB100-92443] - Western blot (WB) analysis of CABLES1 (K588) antibody in extracts from LOVO cells.

CABLES1 Antibody - H00091768-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: CABLES1 Antibody [H00091768-B01P] - Analysis of CABLES1 expression in transfected 293T cell line by CABLES1 polyclonal antibody. Lane 1: CABLES1 transfected lysate(40.48 KDa). Lane 2: Non-transfected lysate.

CABLES1 Antibody - NBP1-68237 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CABLES1 Antibody [NBP1-68237] - Analysis of extracts from LOVO cells, using CABLES1 Antibody. The lane on the right is treated with the synthesized peptide.

CABLES1 Polyclonal Antibody - bs-7893R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Ik3-1 antibody produced in rabbit - SAB4300753 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-IK3-1: <B>Cat. No. SAB4300753</B>: Western blot analysis of extracts from LOVO cells using Anti-Ik3-1 antibody. The lane on the right is treated with the synthesized peptide.

Anti-CABLES1 antibody produced in rabbit - SAB4300814 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CABLES1 antibody produced in mouse - SAB1400765 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Polyclonal Anti-CABLES1, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400765</B>: Antibody concentration: 1.0 μg/mL using HeLa cells.

CABLES1 Antibody - C-terminal region (ARP64758_P050) - ARP64758_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CABLES1 antibody - C-terminal region (ARP64759_P050) - ARP64759_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CABLES1 antibody - GTX87964 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-Ik3-1 antibody used in Western blot. GTX87964

Anti -CABLES1 (CDK5 and ABL1 Enzyme Substrate 1, Interactor with CDK3 1, Ik3-1, CABLES) - 124201 from USBiological Life Science

Host Mouse
Clonality Polyclonal

CABLES1 Antibody (OAAF02840) - OAAF02840 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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