| Gene Symbol | CABLES1 |
|---|---|
| Entrez Gene | 91768 |
| Alt Symbol | CABL1, CABLES, HsT2563, IK3-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Cdk5 and Abl enzyme substrate 1 |
| Other Description | CDK5 and ABL1 enzyme substrate 1|interactor with CDK3 1 |
| Swissprots | B4DK60 Q8N3Y8 Q8NA22 Q9BTG1 Q8TDN4 |
| Accessions | ACA05957 EAX01147 EAX01148 Q8TDN4 AF348525 AAL83906 AK025627 AK093243 BAC04107 AK296407 BAG59072 AK304880 BAG65617 BC004124 AAH04124 BC015686 BC037218 AAH37218 EF028204 ABL77400 NM_001100619 NP_001094089 NM_001256438 NP_001243367 NM_138375 NP_612384 NR_023359 |
| Function | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269|PubMed:11585773, ECO:0000269|PubMed:14729625}. |
Cables1 CRISPR/Cas9 KO Plasmid (h) - sc-406704 from Santa Cruz Biotechnology
|
||||||||
Cables1 HDR Plasmid (h) - sc-406704-HDR from Santa Cruz Biotechnology
|
||||||||
Cables1 Double Nickase Plasmid (h) - sc-406704-NIC from Santa Cruz Biotechnology
|
||||||||
Cables1 Double Nickase Plasmid (h2) - sc-406704-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Cables1 CRISPR Activation Plasmid (h) - sc-406704-ACT from Santa Cruz Biotechnology
|
||||||||
Cables1 CRISPR Activation Plasmid (h2) - sc-406704-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Cables1 Lentiviral Activation Particles (h) - sc-406704-LAC from Santa Cruz Biotechnology
|
||||||||
Cables1 Lentiviral Activation Particles (h2) - sc-406704-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Cables1 siRNA (h) - sc-41913 from Santa Cruz Biotechnology
|
||||||||
Cables1 shRNA Plasmid (h) - sc-41913-SH from Santa Cruz Biotechnology
|
||||||||
Cables1 shRNA (h) Lentiviral Particles - sc-41913-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU078681 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5253 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5253 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR08585 from Sigma-Aldrich
|
||||||||
CABLES1 siRNA (Human) - CRJ4078 from Cohesion Biosciences
|
||||||||
CABLES1 - MBS8204887 from MyBioSource
|
||||||||
shRNA set against Human CABLES1 (NM_138375.2) - SHH253137 from Creative biogene
|
||||||||
Human CABLES1 siRNA - orb274579 from Biorbyt
|
||||||||
CABLES1 shRNA Plasmid (Human) - CHJ4078 from Cohesion Biosciences
|
||||||||
CABLES1 miRNA 3'UTR clone - MiUTR4H-TG01554 from Creative biogene
|