CABLES1

Gene Symbol CABLES1
Entrez Gene 91768
Alt Symbol CABL1, CABLES, HsT2563, IK3-1
Species Human
Gene Type protein-coding
Description Cdk5 and Abl enzyme substrate 1
Other Description CDK5 and ABL1 enzyme substrate 1|interactor with CDK3 1
Swissprots B4DK60 Q8N3Y8 Q8NA22 Q9BTG1 Q8TDN4
Accessions ACA05957 EAX01147 EAX01148 Q8TDN4 AF348525 AAL83906 AK025627 AK093243 BAC04107 AK296407 BAG59072 AK304880 BAG65617 BC004124 AAH04124 BC015686 BC037218 AAH37218 EF028204 ABL77400 NM_001100619 NP_001094089 NM_001256438 NP_001243367 NM_138375 NP_612384 NR_023359
Function Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269|PubMed:11585773, ECO:0000269|PubMed:14729625}.

CABLES1-Over-expression-Lysate - LY14849a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CABLES1 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CABLES1 gene‘

CABLES1 293T Cell Transient Overexpression Lysate(Denatured) - H00091768-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

CABLES1 Overexpression Lysate (Denatured) - H00091768-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
CABLES1 transfected lysate.

CABLES1 Overexpression Lysate (Native) - NBP2-05665 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: CABLES1 Overexpression Lysate (Adult Normal) [NBP2-05665] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CABLES1.

Panoply™ Human CABLES1 Knockdown Stable Cell Line - CSC-DC002242 from Creative biogene

Category Cell Line
Species Human
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