| Gene Symbol |
CABLES1
|
| Entrez Gene |
91768
|
| Alt Symbol |
CABL1, CABLES, HsT2563, IK3-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Cdk5 and Abl enzyme substrate 1
|
| Other Description |
CDK5 and ABL1 enzyme substrate 1|interactor with CDK3 1
|
| Swissprots |
B4DK60 Q8N3Y8 Q8NA22 Q9BTG1 Q8TDN4
|
| Accessions |
ACA05957 EAX01147 EAX01148 Q8TDN4 AF348525 AAL83906 AK025627 AK093243 BAC04107 AK296407 BAG59072 AK304880 BAG65617 BC004124 AAH04124 BC015686 BC037218 AAH37218 EF028204 ABL77400 NM_001100619 NP_001094089 NM_001256438 NP_001243367 NM_138375 NP_612384 NR_023359
|
| Function |
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269|PubMed:11585773, ECO:0000269|PubMed:14729625}.
|