CABLES1

Gene Symbol	CABLES1
Entrez Gene	91768
Alt Symbol	CABL1, CABLES, HsT2563, IK3-1
Species	Human
Gene Type	protein-coding
Description	Cdk5 and Abl enzyme substrate 1
Other Description	CDK5 and ABL1 enzyme substrate 1|interactor with CDK3 1
Swissprots	B4DK60 Q8N3Y8 Q8NA22 Q9BTG1 Q8TDN4
Accessions	ACA05957 EAX01147 EAX01148 Q8TDN4 AF348525 AAL83906 AK025627 AK093243 BAC04107 AK296407 BAG59072 AK304880 BAG65617 BC004124 AAH04124 BC015686 BC037218 AAH37218 EF028204 ABL77400 NM_001100619 NP_001094089 NM_001256438 NP_001243367 NM_138375 NP_612384 NR_023359
Function	Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269|PubMed:11585773, ECO:0000269|PubMed:14729625}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CABLES1 full length protein - ab132663 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CABLES1 peptide - ab87824 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

IK3-1 / CABLES1 Antibody Blocking Peptide - LS-E23615 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IK3-1 / CABLES1 Antibody Blocking Peptide - LS-E23616 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CABLES1 Protein - H00091768-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CABLES1 - H00091768-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CABLES1 - H00091768-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CABLES1 fusion protein - ag4251 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CABLES1 fusion protein - ag6848 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ABL1 (Active), GST-tagged - CABLES1-1361H from Creative Biomart Category Protein Source Sf9 Cells Species Human

CABLES1 Blocking Peptide - CBP3452 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Cables1 (K588) Peptide - BS2218P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human CDK5 and ABL1 enzyme substrate 1(CABLES1) - CSB-YP851551HU CSB-EP851551HU CSB-BP851551HU CSB-MP851551HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CABLES1 (full length, N-term HIS tag, transcript variant 1) - TP760796 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

CDK5 and ABL1 enzyme substrate 1 (CABLES1), Recombinant Protein - MBS1365665 from MyBioSource Category Protein Prices $1,430.00, $1,430.00, $1,660.00, $1,660.00, $2,420.00, $2,420.00, $2,865.00, $2,865.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CABLES1 Blocking Peptide - abx162314 from Abbexa Category Peptide Species Human, Mouse, Rat

CABLES1-Antibody-C-term-Blocking-Peptide - BP9828b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CABLES1 Peptide, Human - M34GP02242H from Creative Peptides Category Peptide Source Synthetic. Species Human

CABLES1 Peptide - orb224338 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

CABLES1 Recombinant Protein Antigen - NBP2-56016PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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