SIRT5

Gene Symbol	SIRT5
Entrez Gene	23408
Alt Symbol	SIR2L5
Species	Human
Gene Type	protein-coding
Description	sirtuin 5
Other Description	NAD-dependent deacetylase sirtuin-5|NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial|NAD-dependent protein deacylase sirtuin-5, mitochondrial|silent mating type information regulation 2, S.cerevisiae, homolog 5|sir2-like 5|sirtuin type 5
Swissprots	Q9Y6E6 F5H5Z9 B4DFM4 Q5T295 B4DYJ5 Q5T294 Q9NXA8
Accessions	CAL00159 CAL00160 CAL48201 CAL48202 CAN36295 CAN36296 EAW55332 EAW55333 EAW55334 EAW55335 EAW55336 EAW55337 EAW55338 Q9NXA8 AF083110 AAD40853 AI969140 AJ420496 AK000355 BAA91107 AK094269 AK294162 BAG57485 AK302467 BAG63757 AM393414 CAL38292 BC000126 AAH00126 BC035122 BC035196 BX538030 CAD97975 CA406695 CB155518 DC314190 DR003695 XM_005248967 XP_005249024 XM_005248968 XP_005249025 XM_005248969 XP_005249026 XM_011514443 XP_011512745 XM_011514444 XP_011512746 XM_011514445 XP_011512747 XM_011514446 XP_011512748 NM_001193267 NP_001180196 NM_001242827 NP_001229756 NM_012241 NP_036373 NM_031244 NP_112534
Function	NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. {ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062}.
Subcellular Location	Isoform 2: Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03160, ECO:0000269|PubMed:21143562}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIRT5 / Sirtuin 5 ELISA Kit (Sandwich ELISA) - LS-F8296 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.067 ng/ml Range 0.156-10 ng/ml

Human SIRT5 / Sirtuin 5 ELISA Kit - LS-F12605 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.051 ng/ml Range 0.156 - 10 ng/ml (depending on sample type)

NAD-dependent deacetylase sirtuin-5 (SIRT5/SIR2L5), Human, ELISA Kit - CSB-E17017h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Sirtuin 5 (SIRT5), Human, ELISA Kit - SEE915Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.067ng/mL Range 0.156-10ng/mL

sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , ELISA Kit - MBS706023 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human SIRT5 is typically less than 0.78pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 3.12 pg/ml-200 pg/ml.

Sirtuin 5 (SIRT5), ELISA Kit - MBS2021217 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.067ng/mL. Range 0.156-10ng/mL

ELISA Kit for Sirtuin 5 (SIRT5) - SEE915Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.067ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human NAD-dependent deacetylase sirtuin-5 (SIRT5/SIR2L5) ELISA kit - CSB-E17017h from Cusabio Category ELISA Kit Sensitivity 0.78 pg/ml. Range Request Information

ELISA Kit for Sirtuin 5 (SIRT5) - SEE915Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.067ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Bovine SIRT5 / Sirtuin 5 ELISA Kit (Custom ELISA) - LS-F16152 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse SIRT5 / Sirtuin 5 ELISA Kit (Custom ELISA) - LS-F16150 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Dog SIRT5 / Sirtuin 5 ELISA Kit (Custom ELISA) - LS-F16154 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat SIRT5 / Sirtuin 5 ELISA Kit (Custom ELISA) - LS-F16151 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Chicken SIRT5 / Sirtuin 5 ELISA Kit (Custom ELISA) - LS-F16153 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Sirtuin 5 (SIRT5) ELISA Kit - EKU07356 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.067 ng/mL Range 0.156-10 ng/mL

Human NAD-dependent deacetylase sirtuin-5 ELISA Kit - abx250559 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human Sirtuin 5 ELISA Kit - abx153096 from Abbexa Category ELISA Kit Sensitivity 0.067 ng/ml Range 0.156 ng/ml - 10 ng/ml

Custom Human Sirtuin 5 ELISA - ELH-SIRT5 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Sirtuin 5 (SIRT5), Human, ELISA Kit - DL-SIRT5-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human SIRT5 ELISA Kit - abx571380 from Abbexa Category ELISA Kit Sensitivity 0.067 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Sirtuin 5 ELISA - RAB1702 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human NAD-dependent deacetylase sirtuin-5 (SIRT5/SIR2L5) ELISA Kit - EKC34730 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity Request Information Range Request Information

SIRT5 - EKH2590 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

SIRT5 ELISA Kit (Human) : 96 Wells (OKEH02159) - OKEH02159 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.067 ng/mL Range 0.156 - 10 ng/mL

Custom Human Sirtuin 5 ELISA - ELH-SIRT5-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

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