SIRT5

Gene Symbol SIRT5
Entrez Gene 23408
Alt Symbol SIR2L5
Species Human
Gene Type protein-coding
Description sirtuin 5
Other Description NAD-dependent deacetylase sirtuin-5|NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial|NAD-dependent protein deacylase sirtuin-5, mitochondrial|silent mating type information regulation 2, S.cerevisiae, homolog 5|sir2-like 5|sirtuin type 5
Swissprots Q9Y6E6 F5H5Z9 B4DFM4 Q5T295 B4DYJ5 Q5T294 Q9NXA8
Accessions CAL00159 CAL00160 CAL48201 CAL48202 CAN36295 CAN36296 EAW55332 EAW55333 EAW55334 EAW55335 EAW55336 EAW55337 EAW55338 Q9NXA8 AF083110 AAD40853 AI969140 AJ420496 AK000355 BAA91107 AK094269 AK294162 BAG57485 AK302467 BAG63757 AM393414 CAL38292 BC000126 AAH00126 BC035122 BC035196 BX538030 CAD97975 CA406695 CB155518 DC314190 DR003695 XM_005248967 XP_005249024 XM_005248968 XP_005249025 XM_005248969 XP_005249026 XM_011514443 XP_011512745 XM_011514444 XP_011512746 XM_011514445 XP_011512747 XM_011514446 XP_011512748 NM_001193267 NP_001180196 NM_001242827 NP_001229756 NM_012241 NP_036373 NM_031244 NP_112534
Function NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. {ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062}.
Subcellular Location Isoform 2: Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03160, ECO:0000269|PubMed:21143562}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10381378}.

SirT5 (D5E11) Rabbit mAb - 8779 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5E11
Western blot analysis of extracts from 293 cells, expressing either nontargeting shRNA (293 shNT) or shRNA targeting SirT5 (293 shSirT5), and HCT 116, Raw 264.7, and COS-7 cells using SirT5 (D5E11) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). 293 shNT and 293 shSirT5 cells were kindly provided by David Lombard, University of Michigan.

SirT5 (D8C3) Rabbit mAb - 8782 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8C3
Western blot analysis of extracts from 293 cells, expressing either nontargeting shRNA (293 shNT) or shRNA targeting SirT5 (293 shSirT5), and HCT 116, Raw 264.7, and H-4-II-E cells using SirT5 (D8C3) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). 293 shNT and 293 shSirT5 cells were kindly provided by David Lombard, University of Michigan.

SIRT5 (D-16) - sc-66272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SIRT5 (G-2) - sc-271635 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRT5 (G-2): sc-271635. Western blot analysis of SIRT5 expression in PC-12 (A), Jurkat (B) and MOLT-4 (C) whole cell lysates and human fetal liver (D), mouse kidney (E) and mouse brain (F) tissue extracts.

SIRT5 (FL-310) - sc-135054 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SIRT5 (FL-310): sc-135054. Western blot analysis of SIRT5 expression in non-transfected: sc-117752 (A) and mouse SIRT5 transfected: sc-123559 (B) 293T whole cell lysates and rat small intestine tissue extract (C).

SIRT5 (K-15) - sc-66273 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIRT5 (K-15): sc-66273. Western blot analysis of SIRT5 expression in non-transfected: sc-117752 (A) and mouse SIRT5 transfected: sc-123559 (B) 293T whole cell lysates.

Anti-SIRT5 antibody - ab78982 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab78982 at 5µg/ml staining SIRT5 in kidney tissue.

Anti-SIRT5 antibody - ab49173 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-SIRT5 antibody (ab49173) at 4 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SIRT5 antibody - ab86274 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT5 antibody (ab86274) at 1 µg/ml (5% skim milk/ PBS buffer) + fetal heart lysate at 10 µg with gel concentration: 12%SecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SIRT5 antibody - ab13697 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT5 antibody (ab13697) at 1/1000 dilution + Human intestine lysate

Anti-SIRT5 antibody [EPR5411] - ab108968 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5411
Anti-SIRT5 antibody [EPR5411] (ab108968) at 1/5000 dilution + Human Fetal liver lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), HRP- conjugated at 1/1000 dilution

Anti-SIRT5 antibody - C-terminal - ab135565 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT5 antibody - C-terminal (ab135565) at 1/100 dilution + Jurkat cell lysate at 35 µg

Anti-SIRT5 / Sirtuin 5 Antibody (C-Terminus) - LS-C115843 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Chicken
Clonality Polyclonal
Western blot analysis of SIRT5 in human liver tissue lysate with SIRT5 antibody at 1 ug/ml.

Anti-SIRT5 / Sirtuin 5 Antibody (aa99-127) - LS-C161104 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of SIRT5 (arrow) using rabbit polyclonal SIRT5 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SIRT5 gene.

Anti-SIRT5 / Sirtuin 5 Antibody - LS-C190144 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (aa33) - LS-C190248 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (aa98-127, AP) - LS-C217526 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (aa98-127, APC) - LS-C217527 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (aa98-127, Biotin) - LS-C217528 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (aa98-127, FITC) - LS-C217529 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (aa30-46) IHC-plus™ - LS-B2060 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2060 concentration 5 ug/ml.

Anti-SIRT5 / Sirtuin 5 Antibody (aa98-127, Azide-free, HRP) - LS-C217531 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (aa98-127, PE) - LS-C217532 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (C-Terminus, APC) - LS-C220679 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT5 / Sirtuin 5 Antibody (clone 2C4) - LS-C173148 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C4
Anti-SIRT5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SIRT5.
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