SIRT5

Gene Symbol	SIRT5
Entrez Gene	23408
Alt Symbol	SIR2L5
Species	Human
Gene Type	protein-coding
Description	sirtuin 5
Other Description	NAD-dependent deacetylase sirtuin-5|NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial|NAD-dependent protein deacylase sirtuin-5, mitochondrial|silent mating type information regulation 2, S.cerevisiae, homolog 5|sir2-like 5|sirtuin type 5
Swissprots	Q9Y6E6 F5H5Z9 B4DFM4 Q5T295 B4DYJ5 Q5T294 Q9NXA8
Accessions	CAL00159 CAL00160 CAL48201 CAL48202 CAN36295 CAN36296 EAW55332 EAW55333 EAW55334 EAW55335 EAW55336 EAW55337 EAW55338 Q9NXA8 AF083110 AAD40853 AI969140 AJ420496 AK000355 BAA91107 AK094269 AK294162 BAG57485 AK302467 BAG63757 AM393414 CAL38292 BC000126 AAH00126 BC035122 BC035196 BX538030 CAD97975 CA406695 CB155518 DC314190 DR003695 XM_005248967 XP_005249024 XM_005248968 XP_005249025 XM_005248969 XP_005249026 XM_011514443 XP_011512745 XM_011514444 XP_011512746 XM_011514445 XP_011512747 XM_011514446 XP_011512748 NM_001193267 NP_001180196 NM_001242827 NP_001229756 NM_012241 NP_036373 NM_031244 NP_112534
Function	NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. {ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062}.
Subcellular Location	Isoform 2: Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03160, ECO:0000269|PubMed:21143562}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SIRT5 full length protein - ab101134 from Abcam Category Protein Prices $302.00, $410.00 Sizes 5 µg, 10 µg Source Baculovirus Species Human

Active human SIRT5 full length protein - ab109032 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source E. coli Species Human

Human SIRT5 full length protein - ab101133 from Abcam Category Protein Source E. coli Species Human

Human SIRT5 full length protein - ab176062 from Abcam Category Protein Source E. coli Species Human

Human SIRT5 full length protein - ab176958 from Abcam Category Protein Source E. coli Species Human

Human SIRT5 full length protein - ab80210 from Abcam Category Protein Source E. coli Species Human

Human SIRT5 full length protein - ab88038 from Abcam Category Protein Source E. coli Species Human

SIRT5 peptide - ab123888 from Abcam Category Peptide

SIRT5 / Sirtuin 5 Antibody Blocking Peptide - LS-E3398 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT5 / Sirtuin 5 Antibody Blocking Peptide - LS-E14591 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT5 / Sirtuin 5 Antibody Blocking Peptide - LS-E14592 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT5 / Sirtuin 5 Antibody Blocking Peptide - LS-E8148 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT5 / Sirtuin 5 Antibody Blocking Peptide - LS-E30935 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SIRT5 / Sirtuin 5 Antibody Blocking Peptide - LS-E11340 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Sirtuin 5/SIRT5 Recombinant Protein - H00023408-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Sirtuin 5/SIRT5 Protein - NBP2-22807 from Novus Biologicals Category Protein Prices $309.00 Sizes 100 µg Species Human

Sirtuin 5/SIRT5 Peptide - NBP1-76266PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Sirtuin 5/SIRT5 Peptide - P1849 from Novus Biologicals Category Peptide Species Human

SIRT5-Antibody-Center-Blocking-Peptide - BP14574c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRT5-Antibody-C-term-Blocking-Peptide - BP6244a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRT5 Peptide - GTX85104-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Sirt5 protein - orb85120 from Biorbyt Category Protein Prices $553.00 Sizes 50 μg Species Human

SIRT5 Blocking Peptide - 33R-7151 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIRT5 Blocking Peptide - 33R-10671 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

SIRT5 Blocking Peptide - 33R-3698 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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