SIRT5

Gene Symbol SIRT5
Entrez Gene 23408
Alt Symbol SIR2L5
Species Human
Gene Type protein-coding
Description sirtuin 5
Other Description NAD-dependent deacetylase sirtuin-5|NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial|NAD-dependent protein deacylase sirtuin-5, mitochondrial|silent mating type information regulation 2, S.cerevisiae, homolog 5|sir2-like 5|sirtuin type 5
Swissprots Q9Y6E6 F5H5Z9 B4DFM4 Q5T295 B4DYJ5 Q5T294 Q9NXA8
Accessions CAL00159 CAL00160 CAL48201 CAL48202 CAN36295 CAN36296 EAW55332 EAW55333 EAW55334 EAW55335 EAW55336 EAW55337 EAW55338 Q9NXA8 AF083110 AAD40853 AI969140 AJ420496 AK000355 BAA91107 AK094269 AK294162 BAG57485 AK302467 BAG63757 AM393414 CAL38292 BC000126 AAH00126 BC035122 BC035196 BX538030 CAD97975 CA406695 CB155518 DC314190 DR003695 XM_005248967 XP_005249024 XM_005248968 XP_005249025 XM_005248969 XP_005249026 XM_011514443 XP_011512745 XM_011514444 XP_011512746 XM_011514445 XP_011512747 XM_011514446 XP_011512748 NM_001193267 NP_001180196 NM_001242827 NP_001229756 NM_012241 NP_036373 NM_031244 NP_112534
Function NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. {ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062}.
Subcellular Location Isoform 2: Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03160, ECO:0000269|PubMed:21143562}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10381378}.

SIRT5 CRISPR/Cas9 KO Plasmid (h) - sc-416994 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT5 HDR Plasmid (h) - sc-416994-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT5 Double Nickase Plasmid (h) - sc-416994-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT5 Double Nickase Plasmid (h2) - sc-416994-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT5 CRISPR Activation Plasmid (h) - sc-416994-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT5 CRISPR Activation Plasmid (h2) - sc-416994-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT5 Lentiviral Activation Particles (h) - sc-416994-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT5 Lentiviral Activation Particles (h2) - sc-416994-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT5 siRNA (h) - sc-63026 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIRT5 shRNA Plasmid (h) - sc-63026-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIRT5 shRNA (h) Lentiviral Particles - sc-63026-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sirtuin 5/SIRT5 RNAi - H00023408-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Sirtuin 5/SIRT5 RNAi - H00023408-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU132521 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19362 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19362 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08914 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08914

SIRT5 siRNA (Human) - CRH8247 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIRT5 - MBS8207125 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SIRT5 (NM_012241.4) - SHH407776 from Creative biogene

Category siRNA
Species Reactivities Human

Human SIRT5 siRNA - orb268749 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIRT5 shRNA Plasmid (Human) - CHH8247 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SIRT5 miRNA 3'UTR clone - MiUTR3H-06846 from Creative biogene

Species Reactivities Human
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