| Gene Symbol |
SIRT5
|
| Entrez Gene |
23408
|
| Alt Symbol |
SIR2L5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sirtuin 5
|
| Other Description |
NAD-dependent deacetylase sirtuin-5|NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial|NAD-dependent protein deacylase sirtuin-5, mitochondrial|silent mating type information regulation 2, S.cerevisiae, homolog 5|sir2-like 5|sirtuin type 5
|
| Swissprots |
Q9Y6E6 F5H5Z9 B4DFM4 Q5T295 B4DYJ5 Q5T294 Q9NXA8
|
| Accessions |
CAL00159 CAL00160 CAL48201 CAL48202 CAN36295 CAN36296 EAW55332 EAW55333 EAW55334 EAW55335 EAW55336 EAW55337 EAW55338 Q9NXA8 AF083110 AAD40853 AI969140 AJ420496 AK000355 BAA91107 AK094269 AK294162 BAG57485 AK302467 BAG63757 AM393414 CAL38292 BC000126 AAH00126 BC035122 BC035196 BX538030 CAD97975 CA406695 CB155518 DC314190 DR003695 XM_005248967 XP_005249024 XM_005248968 XP_005249025 XM_005248969 XP_005249026 XM_011514443 XP_011512745 XM_011514444 XP_011512746 XM_011514445 XP_011512747 XM_011514446 XP_011512748 NM_001193267 NP_001180196 NM_001242827 NP_001229756 NM_012241 NP_036373 NM_031244 NP_112534
|
| Function |
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. {ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062}.
|
| Subcellular Location |
Isoform 2: Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03160, ECO:0000269|PubMed:21143562}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10381378}.
|