USP13

Gene Symbol	USP13
Entrez Gene	8975
Alt Symbol	ISOT3, IsoT-3
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 13 (isopeptidase T-3)
Other Description	deubiquitinating enzyme 13|ubiquitin carboxyl-terminal hydrolase 13|ubiquitin specific protease 13 (isopeptidase T-3)|ubiquitin thioesterase 13|ubiquitin thiolesterase 13|ubiquitin-specific-processing protease 13
Swissprots	A8K2S3 D3DNS2 B4DYF3 Q96B25 Q92995
Accessions	EAW78383 EAW78384 Q92995 AK091484 AK290338 BAF83027 AK302404 BAG63715 AM393315 CAL38193 AM393392 CAL38270 AM393610 CAL38486 AM393780 CAL38655 BC016146 AAH16146 BC049199 BC062766 DQ892472 ABM83398 DQ895684 ABM86610 HM138083 ADM34989 U75362 AAC63405 XM_011513269 XP_011511571 NM_003940 NP_003931
Function	Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak
Tissue Specificity	Highly expressed in ovary and testes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP13 293T Cell Transient Overexpression Lysate(Denatured) - H00008975-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

USP13 293 Cell Lysate - 401186 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

USP13 Overexpression Lysate (Native) - NBL1-17645 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

USP13 (h5): 293T Lysate - sc-174342 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

USP13 Over-expression Lysate Product - GWB-4C57D4 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

USP13 Overexpression Lysate (Denatured) - H00008975-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human USP13 Knockdown Stable Cell Line - CSC-DC017150 from Creative biogene Category Cell Line Species Human

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