USP13

Gene Symbol	USP13
Entrez Gene	8975
Alt Symbol	ISOT3, IsoT-3
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 13 (isopeptidase T-3)
Other Description	deubiquitinating enzyme 13|ubiquitin carboxyl-terminal hydrolase 13|ubiquitin specific protease 13 (isopeptidase T-3)|ubiquitin thioesterase 13|ubiquitin thiolesterase 13|ubiquitin-specific-processing protease 13
Swissprots	A8K2S3 D3DNS2 B4DYF3 Q96B25 Q92995
Accessions	EAW78383 EAW78384 Q92995 AK091484 AK290338 BAF83027 AK302404 BAG63715 AM393315 CAL38193 AM393392 CAL38270 AM393610 CAL38486 AM393780 CAL38655 BC016146 AAH16146 BC049199 BC062766 DQ892472 ABM83398 DQ895684 ABM86610 HM138083 ADM34989 U75362 AAC63405 XM_011513269 XP_011511571 NM_003940 NP_003931
Function	Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak
Tissue Specificity	Highly expressed in ovary and testes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human USP13 full length protein - ab160279 from Abcam Category Protein Source Wheat germ Species Human

USP13 Antibody Blocking Peptide - LS-E21697 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP13 Antibody Blocking Peptide - LS-E6889 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP13 Antibody Blocking Peptide - LS-E6890 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human USP13 Protein - H00008975-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

USP13 Peptide - P0936 from Novus Biologicals Category Peptide Species Human

USP13 Peptide - P0935 from Novus Biologicals Category Peptide Species Human

USP13-Antibody-N-term-Blocking-Peptide - BP14518a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP13-Antibody-Center-Blocking-Peptide - BP2141c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP13-Antibody-N-term-Blocking-Peptide - BP2141a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP13 Blocking Peptide - 33R-9111 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP13 - H00008975-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP13 - H00008975-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

USP13 fusion protein - Ag10527 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

USP13 fusion protein - Ag10506 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human USP13, GST-tagged - USP13-3616H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 13(USP13) ,partial - CSB-YP838823HU CSB-EP838823HU CSB-BP838823HU CSB-MP838823HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human His6-USP13 Protein, CF - E-588 from R&D Systems Category Protein Prices $289.00 Sizes 50 µg Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Contains an C-terminal 6-His tag Species Human

USP13 - TP302190 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

USP13 Recombinant Protein Antigen - NBP1-83088PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

USP13 Peptide, Human - M34GP17150H from Creative Peptides Category Peptide Source Synthetic. Species Human

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