| Gene Symbol |
USP13
|
| Entrez Gene |
8975
|
| Alt Symbol |
ISOT3, IsoT-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 13 (isopeptidase T-3)
|
| Other Description |
deubiquitinating enzyme 13|ubiquitin carboxyl-terminal hydrolase 13|ubiquitin specific protease 13 (isopeptidase T-3)|ubiquitin thioesterase 13|ubiquitin thiolesterase 13|ubiquitin-specific-processing protease 13
|
| Swissprots |
A8K2S3 D3DNS2 B4DYF3 Q96B25 Q92995
|
| Accessions |
EAW78383 EAW78384 Q92995 AK091484 AK290338 BAF83027 AK302404 BAG63715 AM393315 CAL38193 AM393392 CAL38270 AM393610 CAL38486 AM393780 CAL38655 BC016146 AAH16146 BC049199 BC062766 DQ892472 ABM83398 DQ895684 ABM86610 HM138083 ADM34989 U75362 AAC63405 XM_011513269 XP_011511571 NM_003940 NP_003931
|
| Function |
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak
|
| Tissue Specificity |
Highly expressed in ovary and testes.
|