| Gene Symbol | USP13 |
|---|---|
| Entrez Gene | 8975 |
| Alt Symbol | ISOT3, IsoT-3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin specific peptidase 13 (isopeptidase T-3) |
| Other Description | deubiquitinating enzyme 13|ubiquitin carboxyl-terminal hydrolase 13|ubiquitin specific protease 13 (isopeptidase T-3)|ubiquitin thioesterase 13|ubiquitin thiolesterase 13|ubiquitin-specific-processing protease 13 |
| Swissprots | A8K2S3 D3DNS2 B4DYF3 Q96B25 Q92995 |
| Accessions | EAW78383 EAW78384 Q92995 AK091484 AK290338 BAF83027 AK302404 BAG63715 AM393315 CAL38193 AM393392 CAL38270 AM393610 CAL38486 AM393780 CAL38655 BC016146 AAH16146 BC049199 BC062766 DQ892472 ABM83398 DQ895684 ABM86610 HM138083 ADM34989 U75362 AAC63405 XM_011513269 XP_011511571 NM_003940 NP_003931 |
| Function | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak |
| Tissue Specificity | Highly expressed in ovary and testes. |
USP13 CRISPR/Cas9 KO Plasmid (h) - sc-406622 from Santa Cruz Biotechnology
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USP13 HDR Plasmid (h) - sc-406622-HDR from Santa Cruz Biotechnology
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USP13 Double Nickase Plasmid (h) - sc-406622-NIC from Santa Cruz Biotechnology
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USP13 Double Nickase Plasmid (h2) - sc-406622-NIC-2 from Santa Cruz Biotechnology
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USP13 CRISPR Activation Plasmid (h) - sc-406622-ACT from Santa Cruz Biotechnology
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USP13 CRISPR Activation Plasmid (h2) - sc-406622-ACT-2 from Santa Cruz Biotechnology
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USP13 Lentiviral Activation Particles (h) - sc-406622-LAC from Santa Cruz Biotechnology
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USP13 Lentiviral Activation Particles (h2) - sc-406622-LAC-2 from Santa Cruz Biotechnology
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USP13 siRNA (h) - sc-76815 from Santa Cruz Biotechnology
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USP13 shRNA Plasmid (h) - sc-76815-SH from Santa Cruz Biotechnology
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USP13 shRNA (h) Lentiviral Particles - sc-76815-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU003961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22559 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22559 from Sigma-Aldrich
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USP13 siRNA (Human) - CRH5925 from Cohesion Biosciences
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USP13 - MBS8212559 from MyBioSource
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shRNA set against Human USP13 (NM_003940.2) - SHH441248 from Creative biogene
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USP13 CRISPR/Cas9 KO Plasmid (h2) - sc-406622-KO-2 from Santa Cruz Biotechnology
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USP13 HDR Plasmid (h2) - sc-406622-HDR-2 from Santa Cruz Biotechnology
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Human USP13 siRNA - orb266427 from Biorbyt
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USP13 shRNA Plasmid (Human) - CHH5925 from Cohesion Biosciences
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