TEC

Gene Symbol	TEC
Entrez Gene	7006
Alt Symbol	PSCTK4
Species	Human
Gene Type	protein-coding
Description	tec protein tyrosine kinase
Other Description	tyrosine-protein kinase Tec
Swissprots	P42680 Q3MIS5 B7ZKZ6
Accessions	AAB60411 EAW93054 EAW93055 P42680 BC101711 AAI01712 BC101713 AAI01714 BC143487 AAI43488 D29767 BAA06171 XM_011513735 XP_011512037 XM_011513736 XP_011512038 XM_011513737 XP_011512039 XM_011513738 XP_011512040 XM_011513739 XP_011512041 XM_011513740 XP_011512042 XM_011513741 XP_011512043 XR_925160 XR_925161 NM_003215 NP_003206
Function	Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.
Top Pathways	T cell receptor signaling pathway, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phosphotyrosine TEC / Tyrosine-protein Kinase Tec ELISA Kit - RAB1000 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human TEC ELISA Kit (Sandwich ELISA) - LS-F12709 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Tyrosine-protein kinase Tec (TEC), Human, ELISA Kit - CSB-EL023367HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

tec protein tyrosine kinase, ELISA Kit - MBS903920 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Tyrosine-protein kinase Tec(TEC) ELISA kit - CSB-EL023367HU from Cusabio Category ELISA Kit Sensitivity 3.91 pg/ml. Range Request Information

Mouse TEC ELISA Kit (Custom ELISA) - LS-F20148 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

TEC ELISA Kit (Human) : 96 Wells (OKEH01841) - OKEH01841 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.076 ng/mL Range 0.156 - 10 ng/mL

Human Phosphotyrosine TEC ELISA - PEL-TEC-Y-1 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,560.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Tyrosine-protein kinase Tec ELISA Kit - EK4792 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Range 0.156-10 ng/mL

Tyrosine-protein kinase Tec, ELISA Kit - MBS289920 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Tyrosine-protein kinase Tec, ELISA Kit - MBS9428618 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.076ng/mL Range 0.156-10 ng/mL

Tyrosine-protein kinase Tec, ELISA Kit - MBS762040 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human TEC ELISA Kit (Sandwich ELISA) - LS-F35753 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

Tyrosine-Protein Kinase Tec (TEC), ELISA Kit - MBS9397342 from MyBioSource Category ELISA Kit

Tyrosine-Protein Kinase Tec (TEC), ELISA Kit - MBS9397350 from MyBioSource Category ELISA Kit

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