TEC

Gene Symbol	TEC
Entrez Gene	7006
Alt Symbol	PSCTK4
Species	Human
Gene Type	protein-coding
Description	tec protein tyrosine kinase
Other Description	tyrosine-protein kinase Tec
Swissprots	P42680 Q3MIS5 B7ZKZ6
Accessions	AAB60411 EAW93054 EAW93055 P42680 BC101711 AAI01712 BC101713 AAI01714 BC143487 AAI43488 D29767 BAA06171 XM_011513735 XP_011512037 XM_011513736 XP_011512038 XM_011513737 XP_011512039 XM_011513738 XP_011512040 XM_011513739 XP_011512041 XM_011513740 XP_011512042 XM_011513741 XP_011512043 XR_925160 XR_925161 NM_003215 NP_003206
Function	Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.
Top Pathways	T cell receptor signaling pathway, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Tec full length protein - ab105197 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human Tec protein fragment - ab159665 from Abcam Category Protein Source Wheat germ Species Human

TEC-Antibody-N-term-Blocking-Peptide - BP16402a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TEC-Antibody-Center-Blocking-Peptide - BP7721c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TEC - H00007006-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TEC - H00007006-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TEC - P5648 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

TEC fusion protein - ag12554 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TEC fusion protein - Ag12804 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Tec Protein Tyrosine Kinase, GST-tagged - TEC-2621H from Creative Biomart Category Protein Source baculovirus .

Recombinant Human Tec Protein Tyrosine Kinase, GST-tagged - TEC-1111H from Creative Biomart Category Protein Species Human

Tec Protein, activated, 10 µg - 14-801 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg also available in 250μg size --call for pricing and availability and reference catalog number Source Expressed by baculovirus in Sf21 insect cells. Species Human

Recombinant Human Tyrosine-protein kinase Tec(TEC) - CSB-YP023367HU CSB-EP023367HU CSB-BP023367HU CSB-MP023367HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TEC (full length, N-term HIS tag) - TP760589 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Recombinant Tec Protein Tyrosine Kinase (TEC) - RPC786Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Tec Protein Tyrosine Kinase (TEC) - RPC786Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Tec Protein Tyrosine Kinase (TEC) - RPC786Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Thrombospondin 2/TEC, transfected HEK293 cell lysate - 230-10171-100 from RayBiotech Category Protein Prices $135.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Tec Protein, activated, 250 µg - 14-801M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-801) and in bulk (cat# 14-801-K) Source Expressed by baculovirus in Sf21 insect cells.

TEC-Blocking-Peptide-Center - BP21065a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TEC Recombinant Protein (OPCD00612) - OPCD00612 from Aviva Systems Biology Category Protein Source E.coli Species Human

Tec Recombinant Protein Antigen - NBP2-55192PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Tec Protein Tyrosine Kinase, Recombinant Protein - MBS2033272 from MyBioSource Category Protein Prices $165.00, $335.00, $520.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Tec Protein Tyrosine Kinase, Recombinant Protein - MBS2033066 from MyBioSource Category Protein Prices $140.00, $260.00, $400.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

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