TEC

Gene Symbol	TEC
Entrez Gene	7006
Alt Symbol	PSCTK4
Species	Human
Gene Type	protein-coding
Description	tec protein tyrosine kinase
Other Description	tyrosine-protein kinase Tec
Swissprots	P42680 Q3MIS5 B7ZKZ6
Accessions	AAB60411 EAW93054 EAW93055 P42680 BC101711 AAI01712 BC101713 AAI01714 BC143487 AAI43488 D29767 BAA06171 XM_011513735 XP_011512037 XM_011513736 XP_011512038 XM_011513737 XP_011512039 XM_011513738 XP_011512040 XM_011513739 XP_011512041 XM_011513740 XP_011512042 XM_011513741 XP_011512043 XR_925160 XR_925161 NM_003215 NP_003206
Function	Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.
Top Pathways	T cell receptor signaling pathway, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Tec CRISPR/Cas9 KO Plasmid (h) - sc-402051 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tec HDR Plasmid (h) - sc-402051-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tec Double Nickase Plasmid (h) - sc-402051-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tec Double Nickase Plasmid (h2) - sc-402051-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tec CRISPR Activation Plasmid (h) - sc-402051-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tec CRISPR Activation Plasmid (h2) - sc-402051-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tec Lentiviral Activation Particles (h) - sc-402051-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tec Lentiviral Activation Particles (h2) - sc-402051-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tec siRNA (h) - sc-36633 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tec shRNA Plasmid (h) - sc-36633-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tec shRNA (h) Lentiviral Particles - sc-36633-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU013521 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2253 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2254 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2252 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN21199 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21199 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10062 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10062

TEC siRNA (Human) - CRH4783 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TEC - MBS8226436 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Tec (NM_003215.2) - SHH425468 from Creative biogene Category siRNA Species Reactivities Human

Human TEC siRNA - orb265285 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TEC shRNA Plasmid (Human) - CHH4783 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TEC miRNA 3'UTR clone - MiUTR1H-10307 from Creative biogene Species Reactivities Human

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