TEC

Gene Symbol	TEC
Entrez Gene	7006
Alt Symbol	PSCTK4
Species	Human
Gene Type	protein-coding
Description	tec protein tyrosine kinase
Other Description	tyrosine-protein kinase Tec
Swissprots	P42680 Q3MIS5 B7ZKZ6
Accessions	AAB60411 EAW93054 EAW93055 P42680 BC101711 AAI01712 BC101713 AAI01714 BC143487 AAI43488 D29767 BAA06171 XM_011513735 XP_011512037 XM_011513736 XP_011512038 XM_011513737 XP_011512039 XM_011513738 XP_011512040 XM_011513739 XP_011512041 XM_011513740 XP_011512042 XM_011513741 XP_011512043 XR_925160 XR_925161 NM_003215 NP_003206
Function	Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.
Top Pathways	T cell receptor signaling pathway, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Tec Antibody - 4987 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Tec (G-5) - sc-365533 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Tec (H-17) - sc-30709 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Tec (H-90) - sc-25427 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Tec (M-20) - sc-1109 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Tec antibody - ab129599 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Tec antibody [3A5] - ab130258 from Abcam Host Mouse Clonality Monoclonal Clone 3A5

Anti-Tec antibody [Y398] - ab32368 from Abcam Prices $99.00, $387.00 Sizes 10 µl, 100 µl Host Rabbit Clonality Monoclonal Clone Y398

Anti-Tec antibody - C-terminal - ab191013 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (aa26-55, PE) - LS-C271257 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (aa177-205) - LS-C164588 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (Internal, AP) - LS-C283450 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (Internal, APC) - LS-C283451 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (Internal, Biotin) - LS-C283452 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (Internal, Azide-free, HRP) - LS-C283454 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (Internal, FITC) - LS-C283453 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (Internal, PE) - LS-C283455 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (aa176-205) - LS-C325655 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (aa25-55) - LS-C325656 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (Internal) - LS-C328859 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (aa175-205) - LS-C99392 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody (clone 3A5) - LS-C109122 from LifeSpan Bioscience Prices $320.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3A5

Anti-TEC Antibody (clone 1C11) - LS-C198323 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C11

Anti-TEC Antibody (aa177-205, AP) - LS-C271246 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TEC Antibody - LS-C155327 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Search more