| Gene Symbol |
TEC
|
| Entrez Gene |
7006
|
| Alt Symbol |
PSCTK4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tec protein tyrosine kinase
|
| Other Description |
tyrosine-protein kinase Tec
|
| Swissprots |
P42680 Q3MIS5 B7ZKZ6
|
| Accessions |
AAB60411 EAW93054 EAW93055 P42680 BC101711 AAI01712 BC101713 AAI01714 BC143487 AAI43488 D29767 BAA06171 XM_011513735 XP_011512037 XM_011513736 XP_011512038 XM_011513737 XP_011512039 XM_011513738 XP_011512040 XM_011513739 XP_011512041 XM_011513740 XP_011512042 XM_011513741 XP_011512043 XR_925160 XR_925161 NM_003215 NP_003206
|
| Function |
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth
|
| Subcellular Location |
Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.
|
| Top Pathways |
T cell receptor signaling pathway, Osteoclast differentiation
|