UNC5B

Gene Symbol UNC5B
Entrez Gene 219699
Alt Symbol UNC5H2, p53RDL1
Species Human
Gene Type protein-coding
Description unc-5 homolog B (C. elegans)
Other Description netrin receptor UNC5B|p53-regulated receptor for death and life protein 1|protein unc-5 homolog 2|protein unc-5 homolog B|transmembrane receptor Unc5H2|unc-5 homolog 2
Swissprots Q9H9F3 Q86SN3 Q8IZJ1 Q8N1Y2 Q5T3S0 Q5T3R9
Accessions EAW54420 EAW54421 Q8IZJ1 AB096256 BAC57998 AK022859 BAB14276 AK094595 BAC04382 AK128132 BAG54634 AL049370 AY126437 AAM95701 AY358351 AAQ88717 BC166694 AAI66694 BP344031 BQ638420 DA810535 DR003631 XM_011539453 XP_011537755 XR_945617 NM_001244889 NP_001231818 NM_170744 NP_734465
Function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. {ECO:0000269|PubMed:12598906, ECO:0000269|PubMed:15729359}.
Subcellular Location Membrane {ECO:0000269|PubMed:18582460}; Single-pass type I membrane protein {ECO:0000269|PubMed:18582460}. Note=Associated with lipid raft.
Tissue Specificity Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269|PubMed:12359238}.
Top Pathways Axon guidance

UNC5B (D9M7Z) Rabbit mAb - 13851 from Cell Signaling Technology

Prices $261.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9M7Z
Western blot analysis of extracts from various cell lines and tissues using UNC5B (D9M7Z) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

UNC5H2 (H-43) - sc-98865 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

UNC5H2 (N-19) - sc-28047 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UNC5H2 (Q-20) - sc-28048 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-UNC5B antibody - ab104871 from Abcam

Prices $379.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraformaldehyde-perfusion fixed Rat brain tissue, staining UNC5B (red) with ab104871 at 1/300 dilution.

Anti-UNC5B antibody [Guido-1] - ab54430 from Abcam

Prices $388.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone Guido-1
ab54430 staining UNC5B in mouse erythrocytes by Flow Cytometry. Collected heparinised mouse blood was incubated with erythrocyte lysing solution for 5 minutes at room temperature. The cells were washed and incubated with the primary antibody, CD45 as a general marker for leukocytes (green) and F4/80 to label macrophages (blue).

Anti-UNC5B antibody - Azide free - ab201258 from Abcam

Prices $1,020.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H2 / UNC5B Antibody - LS-C144985 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H2 / UNC5B Antibody - LS-C153498 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UNC5H2 / UNC5B Antibody (aa632-645) - LS-C155066 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-UNC5H2 / UNC5B Antibody (clone Guido-1) - LS-C343684 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Guido-1

Anti-UNC5H2 / UNC5B Antibody (aa629-643) - LS-C205077 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
UNC5B antibody (2 ug/ml) staining of Human Bone Marrow lysate (35 ug protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.

UNC5H2/UNC5B Antibody - NBP2-26090 from Novus Biologicals

Prices $249.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

UNC5H2/UNC5B Antibody (1A9) - H00219699-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A9
Sandwich ELISA: UNC5H2/UNC5B Antibody (1A9) [H00219699-M01] - Detection limit for recombinant GST tagged UNC5B is approximately 1ng/ml as a capture antibody.

UNC5H2/UNC5B Antibody - NBP1-87367 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: UNC5H2/UNC5B Antibody [NBP1-87367] - Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.

UNC5H2/UNC5B Antibody - H00219699-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

UNC5B/UNC5H2 Polyclonal Antibody - bs-11492R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded mouse stomach; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with UNC5B/UNC5H2 Polyclonal Antibody, Unconjugated (bs-11492R) at 1:400 overnight at 4°C, followed by a conjugated secondary (Goat Anti-rabbit IgG/Bio) for 20minutes at 37°C, followed by a conjugated streptavidin at[1:500] for 40 minutes and DAPI staining of the nuclei.

UNC5B/UNC5H2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11492R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC5B/UNC5H2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11492R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC5B/UNC5H2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11492R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC5B/UNC5H2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11492R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC5B/UNC5H2 Polyclonal Antibody, Cy3 Conjugated - bs-11492R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC5B/UNC5H2 Polyclonal Antibody, Cy5 Conjugated - bs-11492R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC5B/UNC5H2 Polyclonal Antibody, Cy5.5 Conjugated - bs-11492R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC5B/UNC5H2 Polyclonal Antibody, Cy7 Conjugated - bs-11492R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more