UNC5B

Gene Symbol UNC5B
Entrez Gene 219699
Alt Symbol UNC5H2, p53RDL1
Species Human
Gene Type protein-coding
Description unc-5 homolog B (C. elegans)
Other Description netrin receptor UNC5B|p53-regulated receptor for death and life protein 1|protein unc-5 homolog 2|protein unc-5 homolog B|transmembrane receptor Unc5H2|unc-5 homolog 2
Swissprots Q9H9F3 Q86SN3 Q8IZJ1 Q8N1Y2 Q5T3S0 Q5T3R9
Accessions EAW54420 EAW54421 Q8IZJ1 AB096256 BAC57998 AK022859 BAB14276 AK094595 BAC04382 AK128132 BAG54634 AL049370 AY126437 AAM95701 AY358351 AAQ88717 BC166694 AAI66694 BP344031 BQ638420 DA810535 DR003631 XM_011539453 XP_011537755 XR_945617 NM_001244889 NP_001231818 NM_170744 NP_734465
Function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. {ECO:0000269|PubMed:12598906, ECO:0000269|PubMed:15729359}.
Subcellular Location Membrane {ECO:0000269|PubMed:18582460}; Single-pass type I membrane protein {ECO:0000269|PubMed:18582460}. Note=Associated with lipid raft.
Tissue Specificity Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269|PubMed:12359238}.
Top Pathways Axon guidance

UNC5H2 CRISPR/Cas9 KO Plasmid (h) - sc-402347 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H2 HDR Plasmid (h) - sc-402347-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H2 Double Nickase Plasmid (h) - sc-402347-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H2 Double Nickase Plasmid (h2) - sc-402347-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H2 CRISPR Activation Plasmid (h) - sc-402347-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H2 CRISPR Activation Plasmid (h2) - sc-402347-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H2 Lentiviral Activation Particles (h) - sc-402347-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H2 Lentiviral Activation Particles (h2) - sc-402347-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H2 siRNA (h) - sc-61846 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC5H2 shRNA Plasmid (h) - sc-61846-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC5H2 shRNA (h) Lentiviral Particles - sc-61846-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC5H2/UNC5B RNAi - H00219699-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU124361 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22501 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22501 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05809 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05809

UNC5B siRNA (Human) - CRJ6404 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC5B - MBS8201102 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UNC5B (NM_170744.4) - SHH440573 from Creative biogene

Category siRNA
Species Reactivities Human

Human UNC5B siRNA - orb276905 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC5B shRNA Plasmid (Human) - CHJ6404 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UNC5B miRNA 3'UTR clone - MiUTR3H-09519 from Creative biogene

Species Reactivities Human
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