UNC5B
| Gene Symbol | UNC5B |
|---|---|
| Entrez Gene | 219699 |
| Alt Symbol | UNC5H2, p53RDL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | unc-5 homolog B (C. elegans) |
| Other Description | netrin receptor UNC5B|p53-regulated receptor for death and life protein 1|protein unc-5 homolog 2|protein unc-5 homolog B|transmembrane receptor Unc5H2|unc-5 homolog 2 |
| Swissprots | Q9H9F3 Q86SN3 Q8IZJ1 Q8N1Y2 Q5T3S0 Q5T3R9 |
| Accessions | EAW54420 EAW54421 Q8IZJ1 AB096256 BAC57998 AK022859 BAB14276 AK094595 BAC04382 AK128132 BAG54634 AL049370 AY126437 AAM95701 AY358351 AAQ88717 BC166694 AAI66694 BP344031 BQ638420 DA810535 DR003631 XM_011539453 XP_011537755 XR_945617 NM_001244889 NP_001231818 NM_170744 NP_734465 |
| Function | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. {ECO:0000269|PubMed:12598906, ECO:0000269|PubMed:15729359}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:18582460}; Single-pass type I membrane protein {ECO:0000269|PubMed:18582460}. Note=Associated with lipid raft. |
| Tissue Specificity | Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269|PubMed:12359238}. |
| Top Pathways | Axon guidance |
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