UNC5B

Gene Symbol	UNC5B
Entrez Gene	219699
Alt Symbol	UNC5H2, p53RDL1
Species	Human
Gene Type	protein-coding
Description	unc-5 homolog B (C. elegans)
Other Description	netrin receptor UNC5B|p53-regulated receptor for death and life protein 1|protein unc-5 homolog 2|protein unc-5 homolog B|transmembrane receptor Unc5H2|unc-5 homolog 2
Swissprots	Q9H9F3 Q86SN3 Q8IZJ1 Q8N1Y2 Q5T3S0 Q5T3R9
Accessions	EAW54420 EAW54421 Q8IZJ1 AB096256 BAC57998 AK022859 BAB14276 AK094595 BAC04382 AK128132 BAG54634 AL049370 AY126437 AAM95701 AY358351 AAQ88717 BC166694 AAI66694 BP344031 BQ638420 DA810535 DR003631 XM_011539453 XP_011537755 XR_945617 NM_001244889 NP_001231818 NM_170744 NP_734465
Function	Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. {ECO:0000269|PubMed:12598906, ECO:0000269|PubMed:15729359}.
Subcellular Location	Membrane {ECO:0000269|PubMed:18582460}; Single-pass type I membrane protein {ECO:0000269|PubMed:18582460}. Note=Associated with lipid raft.
Tissue Specificity	Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269|PubMed:12359238}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Netrin receptor UNC5B (UNC5B), Human, ELISA Kit - CSB-EL025629HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

unc-5 homolog B (C. elegans) , ELISA Kit - MBS933650 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human UNC5B is typically less than 0.078 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.312 ng/ml -20 ng/ml.

Human Netrin receptor UNC5B(UNC5B) ELISA kit - CSB-EL025629HU from Cusabio Category ELISA Kit Sensitivity 0.078ng/ml Range 0.312 ng/ml-20 ng/ml

Human Netrin receptor UNC5B (UNC5B) ELISA Kit - EKC34759 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Human UNC5B ELISA Kit - E102187 from Biobool Category ELISA Kit

UNC5B ELISA Kit (Human) (OKCA01385) - OKCA01385 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 0.078 ng/mL Range 0.312 - 20 ng/mL

UNC5B (Netrin Receptor UNC5B), ELISA Kit - MBS7606261 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/ml Range 0.313-20ng/ml

Human UNC5B ELISA Kit - orb407039 from Biorbyt Category ELISA Kit Sensitivity 0.078ng/ml Range 0.312 ng/ml-20 ng/ml

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