UNC5B

Gene Symbol	UNC5B
Entrez Gene	219699
Alt Symbol	UNC5H2, p53RDL1
Species	Human
Gene Type	protein-coding
Description	unc-5 homolog B (C. elegans)
Other Description	netrin receptor UNC5B|p53-regulated receptor for death and life protein 1|protein unc-5 homolog 2|protein unc-5 homolog B|transmembrane receptor Unc5H2|unc-5 homolog 2
Swissprots	Q9H9F3 Q86SN3 Q8IZJ1 Q8N1Y2 Q5T3S0 Q5T3R9
Accessions	EAW54420 EAW54421 Q8IZJ1 AB096256 BAC57998 AK022859 BAB14276 AK094595 BAC04382 AK128132 BAG54634 AL049370 AY126437 AAM95701 AY358351 AAQ88717 BC166694 AAI66694 BP344031 BQ638420 DA810535 DR003631 XM_011539453 XP_011537755 XR_945617 NM_001244889 NP_001231818 NM_170744 NP_734465
Function	Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. {ECO:0000269|PubMed:12598906, ECO:0000269|PubMed:15729359}.
Subcellular Location	Membrane {ECO:0000269|PubMed:18582460}; Single-pass type I membrane protein {ECO:0000269|PubMed:18582460}. Note=Associated with lipid raft.
Tissue Specificity	Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269|PubMed:12359238}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human UNC5B protein fragment - ab157036 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source CHO Species Human

Human UNC5B protein fragment - ab153628 from Abcam Category Protein Source Wheat germ Species Human

Human UNC5B protein fragment - ab109066 from Abcam Category Protein Source HEK 293 cells Species Human

UNC5H2 / UNC5B Antibody Blocking Peptide - LS-E27969 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UNC5H2/UNC5B Protein - H00219699-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human UNC5H2/UNC5B Protein - H00219699-G01 from Novus Biologicals Category Protein Prices $349.00 Sizes 2 µg Species Human

UNC5B blocking peptide - GTX88394-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Human UNC5B (His Tag) protein - orb232315 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 50 μg, 200 μg Species Human

Human UNC5B (Fc Tag) protein - orb232314 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Species Human

UNC5B Peptide - AC21-2734-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UNC5B - H00219699-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UNC5B - H00219699-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human UNC5B, Fc-tagged - UNC5B-31670TH from Creative Biomart Category Protein Source HEK 293 cells

Recombinant Human Unc-5 Homolog B (C. Elegans), Fc Chimera - UNC5B-2438H from Creative Biomart Category Protein Source CHO cells.

Human UNC5B / UNC5H2 Protein (His Tag, ECD) - 13606-H08H-50 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 50 µg, 200 µg Source Human Cells Species Human

Human UNC5B / UNC5H2 Protein (ECD, Fc Tag) - 13606-H02H-100 from Sino Biological Category Protein Prices $298.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

UNC5B - pro10317 from Covalab Category Protein Source HEK 293 cells Species Human, Mouse

Recombinant Human Netrin receptor UNC5B(UNC5B) - CSB-YP811636HU CSB-EP811636HU CSB-BP811636HU CSB-MP811636HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Human CellExp™ UNC5B, human recombinant - 7576-10 from Biovision Category Protein Prices $195.00 Sizes 10 μg Source HEK293 cells Species Human

UNC5B - TP318267 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

UNC5B, Peptide - MBS428339 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

Recombinant Human UNC5B:Fc Chimera - CRH057A from Cell Science Prices $417.00 Sizes 50 μg Species Human

Recombinant Human UNC5B:Fc Chimera - CRH057B from Cell Science Prices $799.00 Sizes 3 x 50 μg Species Human

Recombinant Human UNC5B Protein, Fc-tagged - UNC5B-555H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human UNC5B Protein, His-tagged - UNC5B-556H from Creative Biomart Category Protein Source HEK293 Species Human

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