| Gene Symbol |
CNR2
|
| Entrez Gene |
1269
|
| Alt Symbol |
CB-2, CB2, CX5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cannabinoid receptor 2 (macrophage)
|
| Other Description |
cannabinoid receptor 2|testis-dominant CNR2 isoform CB2
|
| Swissprots |
P34972 C6ES44 Q6NSY0 Q5JRH7 Q6B0G7 Q4VBK8
|
| Accessions |
AAO92299 CAD22549 CAO02243 CAS97371 CAV28600 CAZ76867 EAW95099 EAW95100 P34972 AJ430063 CAD22548 AM156854 CAJ42137 AM156855 CAJ42138 AM156856 CAJ42139 BC069722 AAH69722 BC074767 AAH74767 BC095545 AAH95545 EU517121 ACD31539 FJ357036 X74328 CAA52376 XM_005245736 XP_005245793 XM_011540627 XP_011538929 XM_011540628 XP_011538930 XM_011540629 XP_011538931 NM_001841 NP_001832
|
| Function |
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.
|
| Tissue Specificity |
Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. {ECO:0000269|PubMed:12153574, ECO:0000269|PubMed:12511587, ECO:0000269|PubMed:14657172, ECO:0000269|PubMed:15266552, ECO:0000269|PubMed:18692962, ECO:0000269|PubMed:19496827, ECO:0000269|PubMed:7556170}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|