CNR2

Gene Symbol	CNR2
Entrez Gene	1269
Alt Symbol	CB-2, CB2, CX5
Species	Human
Gene Type	protein-coding
Description	cannabinoid receptor 2 (macrophage)
Other Description	cannabinoid receptor 2|testis-dominant CNR2 isoform CB2
Swissprots	P34972 C6ES44 Q6NSY0 Q5JRH7 Q6B0G7 Q4VBK8
Accessions	AAO92299 CAD22549 CAO02243 CAS97371 CAV28600 CAZ76867 EAW95099 EAW95100 P34972 AJ430063 CAD22548 AM156854 CAJ42137 AM156855 CAJ42138 AM156856 CAJ42139 BC069722 AAH69722 BC074767 AAH74767 BC095545 AAH95545 EU517121 ACD31539 FJ357036 X74328 CAA52376 XM_005245736 XP_005245793 XM_011540627 XP_011538929 XM_011540628 XP_011538930 XM_011540629 XP_011538931 NM_001841 NP_001832
Function	Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.
Tissue Specificity	Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. {ECO:0000269|PubMed:12153574, ECO:0000269|PubMed:12511587, ECO:0000269|PubMed:14657172, ECO:0000269|PubMed:15266552, ECO:0000269|PubMed:18692962, ECO:0000269|PubMed:19496827, ECO:0000269|PubMed:7556170}.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cannabinoid Receptor II peptide - ab45941 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cannabinoid Receptor II full length protein - ab114225 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human Cannabinoid Receptor II protein fragment - ab152290 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CNR2 / CB2 Antibody Blocking Peptide - LS-E395 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNR2 / CB2 Antibody Blocking Peptide - LS-E28767 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CNR2 / CB2 Antibody Blocking Peptide - LS-E28790 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CNR2 / CB2 Antibody Blocking Peptide - LS-E28717 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CNR2 / CB2 Antibody Blocking Peptide - LS-E28739 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CNR2 / CB2 Antibody Blocking Peptide - LS-E25958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNR2 / CB2 Antibody Blocking Peptide - LS-E23154 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cannabinoid R2/CB2/CNR2 Protein - H00001269-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cannabinoid R2/CB2/CNR2 Protein - H00001269-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CB2-Antibody-C-term-Blocking-peptide - BP10674b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cannabinoid receptor 2 blocking peptide - GTX89424-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Cannabinoid Receptor Ii Peptide - AC21-0785-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Cannabinoid receptor 2 - H00001269-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

Cannabinoid receptor 2 - H00001269-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cannabinoid receptor 2 - H00001269-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cannabinoid receptor 2 - H00001269-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cannabinoid receptor 2 - H00001269-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cannabinoid Receptor 2 Peptide - 45-356P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

CNR2 fusion protein - ag13685 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CNR2 - CNR2-26236TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CNR2 - CNR2-738H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Cannabinoid Receptor 2, Macrophage (CNR2) - RPE045Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

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