CNR2

Gene Symbol	CNR2
Entrez Gene	1269
Alt Symbol	CB-2, CB2, CX5
Species	Human
Gene Type	protein-coding
Description	cannabinoid receptor 2 (macrophage)
Other Description	cannabinoid receptor 2\|testis-dominant CNR2 isoform CB2
Swissprots	P34972 C6ES44 Q6NSY0 Q5JRH7 Q6B0G7 Q4VBK8
Accessions	AAO92299 CAD22549 CAO02243 CAS97371 CAV28600 CAZ76867 EAW95099 EAW95100 P34972 AJ430063 CAD22548 AM156854 CAJ42137 AM156855 CAJ42138 AM156856 CAJ42139 BC069722 AAH69722 BC074767 AAH74767 BC095545 AAH95545 EU517121 ACD31539 FJ357036 X74328 CAA52376 XM_005245736 XP_005245793 XM_011540627 XP_011538929 XM_011540628 XP_011538930 XM_011540629 XP_011538931 NM_001841 NP_001832
Function	Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269\|PubMed:10051546, ECO:0000269\|PubMed:12663043, ECO:0000269\|PubMed:12711605, ECO:0000269\|PubMed:18692962}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.
Tissue Specificity	Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. {ECO:0000269\|PubMed:12153574, ECO:0000269\|PubMed:12511587, ECO:0000269\|PubMed:14657172, ECO:0000269\|PubMed:15266552, ECO:0000269\|PubMed:18692962, ECO:0000269\|PubMed:19496827, ECO:0000269\|PubMed:7556170}.
Top Pathways	Neuroactive ligand-receptor interaction

CB2 (H-60) - sc-25494 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CB2 (H-60): sc-25494. Immunoperoxidase staining of formalin fixed, paraffin-embedded human oral mucosa tissue showing cytoplasmic staining of surface epithelial cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

CB2 (C-15) - sc-10073 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CB2 (S-16) - sc-10071 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CB2 (S-16): sc-10071. Immunoperoxidase staining of formalin fixed, paraffin-embedded human parathyroid gland tissue showing cytoplasmic staining of glandular cells.

Anti-Cannabinoid Receptor II antibody - ab3561 from Abcam

Prices	$400.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ab3561 labelling Cannabinoid Receptor II in the cytoplasm of Human tonsil tissue (right) compared with a negative control (left) by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0) microwaved for 8-15 min. Tissues were blocked in 3% H2O2-methanol for 15 min at room temperature. Tssiue sections were incubated with the primary antibody (1:20 in 3% BSA-PBS) overnight at 4°C. A anti-rabbit HRP was used as the secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.

Anti-Cannabinoid Receptor II antibody - ab45942 from Abcam

Prices	$388.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Cannabinoid Receptor II antibody (ab45942) at 1 µg/mlLane 1 : Spinal Cord (Human) Tissue LysateLane 2 : Spinal Cord (Rat) Tissue Lysate Lane 3 : Thymus (Mouse) Tissue Lysate - normal tissue (ab29285)Lysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-Cannabinoid Receptor II antibody - ab3560 from Abcam

Prices	$381.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ICC/IF image of ab3560 stained SKNSH cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab3560, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Cannabinoid Receptor II antibody - ab151414 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Cannabinoid Receptor II antibody (ab151414) at 1/1000 dilution + PC3 whole cell lysate at 30 µg

Anti-Cannabinoid Receptor II antibody - ab77265 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-Cannabinoid Receptor II antibody (ab77265) at 2 µg/ml + Jurkat cell lysate in RIPA buffer at 35 µg

Anti-Cannabinoid Receptor II antibody - ab123056 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Cannabinoid Receptor II antibody (ab123056) at 1 µg/ml + 721_B cell lysate at 10 µg

Anti-Cannabinoid Receptor II antibody - ab54565 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab54565 Cannabinoid Receptor II antibody at 1ug/ml.

Anti-Cannabinoid Receptor II antibody - C-terminal - ab153747 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Cannabinoid Receptor II antibody - C-terminal (ab153747) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg

Anti-Cannabinoid Receptor II antibody - N-terminal - ab137735 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Cannabinoid Receptor II antibody - N-terminal (ab137735) at 1/1000 dilution + Molt4 whole cell lysate at 30 µg

Anti-Cannabinoid Receptor II antibody - N-terminal - ab150569 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin fixed and paraffin embedded Human tonsil tissue, germinal center and mantle zone labelling Cannabinoid Receptor II with ab150569 at 17 ug/ml after heat-induced antigen retrieval.

Anti-CNR2 / CB2 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A34 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNR2 / CB2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CNR2 / CB2 Antibody (clone 3C7) - LS-C196942 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C7

Immunofluorescence of monoclonal antibody to CNR2 on HeLa cell . [antibody concentration 10 ug/ml]

Anti-CNR2 / CB2 Antibody (aa1-33) IHC-plus™ - LS-B2263 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNR2 / CB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2263 dilution 1:100.

Anti-CNR2 / CB2 Antibody (Internal) IHC-plus™ - LS-A36 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNR2 / CB2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CNR2 / CB2 Antibody (aa331-360) - LS-C168348 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

CB2 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skin carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CNR2 / CB2 Antibody (C-Terminus) - LS-C12380 from LifeSpan Bioscience

Prices	$415.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNR2 / CB2 Antibody (C-Terminus) - LS-C12382 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNR2 / CB2 Antibody (N-Terminus) - LS-C12386 from LifeSpan Bioscience

Prices	$415.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNR2 / CB2 Antibody (aa1-33) - LS-C77673 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNR2 / CB2 Antibody (aa20-33) - LS-C11166 from LifeSpan Bioscience

Prices	$350.00
Sizes	1 ea
Host	Rabbit
Clonality	Polyclonal

Western blot of CNR2 / CB2 antibody LS-C11166.

Anti-CNR2 / CB2 Antibody (C-Terminus) IHC-plus™ - LS-A35 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNR2 / CB2 Antibody (FITC) - LS-C146697 from LifeSpan Bioscience

Prices	$350.00
Sizes	500 µl
Host	Rabbit
Clonality	Polyclonal

Search more