| Gene Symbol | CNR2 |
|---|---|
| Entrez Gene | 1269 |
| Alt Symbol | CB-2, CB2, CX5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cannabinoid receptor 2 (macrophage) |
| Other Description | cannabinoid receptor 2|testis-dominant CNR2 isoform CB2 |
| Swissprots | P34972 C6ES44 Q6NSY0 Q5JRH7 Q6B0G7 Q4VBK8 |
| Accessions | AAO92299 CAD22549 CAO02243 CAS97371 CAV28600 CAZ76867 EAW95099 EAW95100 P34972 AJ430063 CAD22548 AM156854 CAJ42137 AM156855 CAJ42138 AM156856 CAJ42139 BC069722 AAH69722 BC074767 AAH74767 BC095545 AAH95545 EU517121 ACD31539 FJ357036 X74328 CAA52376 XM_005245736 XP_005245793 XM_011540627 XP_011538929 XM_011540628 XP_011538930 XM_011540629 XP_011538931 NM_001841 NP_001832 |
| Function | Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}. |
| Tissue Specificity | Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. {ECO:0000269|PubMed:12153574, ECO:0000269|PubMed:12511587, ECO:0000269|PubMed:14657172, ECO:0000269|PubMed:15266552, ECO:0000269|PubMed:18692962, ECO:0000269|PubMed:19496827, ECO:0000269|PubMed:7556170}. |
| Top Pathways | Neuroactive ligand-receptor interaction |
CB2 CRISPR/Cas9 KO Plasmid (h) - sc-401054 from Santa Cruz Biotechnology
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CB2 HDR Plasmid (h) - sc-401054-HDR from Santa Cruz Biotechnology
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CB2 Double Nickase Plasmid (h) - sc-401054-NIC from Santa Cruz Biotechnology
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CB2 Double Nickase Plasmid (h2) - sc-401054-NIC-2 from Santa Cruz Biotechnology
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CB2 CRISPR Activation Plasmid (h) - sc-401054-ACT from Santa Cruz Biotechnology
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CB2 CRISPR Activation Plasmid (h2) - sc-401054-ACT-2 from Santa Cruz Biotechnology
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CB2 Lentiviral Activation Particles (h) - sc-401054-LAC from Santa Cruz Biotechnology
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CB2 Lentiviral Activation Particles (h2) - sc-401054-LAC-2 from Santa Cruz Biotechnology
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CB2 siRNA (h) - sc-39912 from Santa Cruz Biotechnology
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CB2 shRNA Plasmid (h) - sc-39912-SH from Santa Cruz Biotechnology
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CB2 shRNA (h) Lentiviral Particles - sc-39912-V from Santa Cruz Biotechnology
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Cannabinoid R2/CB2/CNR2 RNAi - H00001269-R02 from Novus Biologicals
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MISSION® esiRNA - EHU120781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2025 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2025 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05238 from Sigma-Aldrich
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CNR2 siRNA (Human) - CRH0889 from Cohesion Biosciences
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CNR2 - MBS8240618 from MyBioSource
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shRNA set against Human CNR2 (NM_001841.2) - SHH266581 from Creative biogene
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Human CNR2 siRNA - orb261391 from Biorbyt
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CNR2 shRNA Plasmid (Human) - CHH0889 from Cohesion Biosciences
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CNR2 miRNA 3'UTR clone - MiUTR3H-07326 from Creative biogene
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