BRCC3

Gene Symbol	BRCC3
Entrez Gene	79184
Alt Symbol	BRCC36, C6.1A, CXorf53
Species	Human
Gene Type	protein-coding
Description	BRCA1/BRCA2-containing complex, subunit 3
Other Description	BRCA1-A complex subunit BRCC36|BRCA1/BRCA2-containing complex subunit 36|BRISC complex subunit BRCC36|lys-63-specific deubiquitinase BRCC36
Swissprots	Q16107 A9Z1Y5 Q9BTZ6 B1B062 B4DQN7 A6QRF8 P46736 Q53YX5 A8MWH0 A6QRF9 A8MUX5 A9Z1Y0
Accessions	EAW72632 EAW72633 EAW72634 EAW72635 EAW72636 EAW72637 P46736 AK298886 BAG60999 AK299194 BAG61237 AK310286 AK313544 BAG36320 AM392829 CAL37707 AY438030 AAR30498 BC002999 AAH02999 BC006540 AAH06540 BP304352 BU902387 S68015 AAB29005 X64643 CAA45917 XM_005274751 XP_005274808 NM_001018055 NP_001018065 NM_001242640 NP_001229569 NM_024332 NP_077308
Function	Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:1920
Subcellular Location	Nucleus {ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. {ECO:0000269|PubMed:16707425}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BRCC3 / BRCC36 ELISA Kit (Sandwich ELISA) - LS-F9958 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.065 ng/ml Range 0.156-10 ng/ml

Human BRCC3 ELISA Kit - abx150837 from Abbexa Category ELISA Kit Sensitivity 0.060 ng/ml Range 0.156 ng/ml - 10 ng/ml

Lys-63-specific deubiquitinase BRCC36 (BRCC3), Human, ELISA Kit - CSB-EL002798HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Lys-63-Specific Deubiquitinase Brcc36, BRCC3/BRCC36, Human, ELISA Kit - YHB1929Hu from ARP American Research Products Category ELISA Kit

BRCA1/BRCA2-containing complex, subunit 3, ELISA Kit - MBS926707 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human BRCC3 is typically less than 11.7 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 46.88 pg/ml -3000 pg/ml.

Lys-63-specific deubiquitinase BRCC36, BRCC3/BRCC36, ELISA Kit - MBS9305340 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) - SEN348Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.060ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Lys-63-specific deubiquitinase BRCC36(BRCC3) ELISA kit - CSB-EL002798HU from Cusabio Category ELISA Kit Sensitivity 11.7 pg/ml Range 46.88 pg/ml-3000 pg/ml

ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) - SEN348Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.060ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Lys-63-specific deubiquitinase BRCC36(BRCC3) ELISA Kit - EKC34494 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 11.7 pg/ml Range 46.88 pg/ml-3000 pg/ml

Human BRCC3 ELISA Kit - E005275 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human BRCC3 is typically less than 11.7 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

Human BRCC3/BRCC36 ELISA Kit - E023189 from Biobool Category ELISA Kit

BRCC3 ELISA Kit (Human) (OKCD00626) - OKCD00626 from Aviva Systems Biology Category ELISA Kit Prices $585.00 Sizes 96 wells Sensitivity < 0.065 ng/mL Range 0.156-10 ng/mL

anti-BRCC36 antibody [3B1] - ARG56990 from Arigo Biolaboratories Category ELISA Kit

Human DEP domain-containing protein 1B (DEPDC1B) ELISA Kit - AE47423HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

Human BRCC3 ELISA Kit - orb405769 from Biorbyt Category ELISA Kit Sensitivity 11.7 pg/ml Range 46.88 pg/ml-3000 pg/ml

Human Lys-63-specific deubiquitinase BRCC36 (BRCC3) ELISA kit - EKC41392 from Biomatik Category ELISA Kit Prices $709.00 Sizes 96 tests Sensitivity 11.7 pg/mL Range 46.88 pg/mL-3000 pg/mL

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