BRCC3

Gene Symbol	BRCC3
Entrez Gene	79184
Alt Symbol	BRCC36, C6.1A, CXorf53
Species	Human
Gene Type	protein-coding
Description	BRCA1/BRCA2-containing complex, subunit 3
Other Description	BRCA1-A complex subunit BRCC36|BRCA1/BRCA2-containing complex subunit 36|BRISC complex subunit BRCC36|lys-63-specific deubiquitinase BRCC36
Swissprots	Q16107 A9Z1Y5 Q9BTZ6 B1B062 B4DQN7 A6QRF8 P46736 Q53YX5 A8MWH0 A6QRF9 A8MUX5 A9Z1Y0
Accessions	EAW72632 EAW72633 EAW72634 EAW72635 EAW72636 EAW72637 P46736 AK298886 BAG60999 AK299194 BAG61237 AK310286 AK313544 BAG36320 AM392829 CAL37707 AY438030 AAR30498 BC002999 AAH02999 BC006540 AAH06540 BP304352 BU902387 S68015 AAB29005 X64643 CAA45917 XM_005274751 XP_005274808 NM_001018055 NP_001018065 NM_001242640 NP_001229569 NM_024332 NP_077308
Function	Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:1920
Subcellular Location	Nucleus {ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. {ECO:0000269|PubMed:16707425}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BRCC3 293T Cell Transient Overexpression Lysate(Denatured) - H00079184-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

BRCC3 overexpression lysate - LY411291 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

BRCC3 overexpression lysate - LY422709 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

BRCC3 overexpression lysate - LY425421 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

BRCC3 293 Cell Lysate - 405662 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

BRCC3 Over-expression Lysate Product - GWB-33B920 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

BRCC3 Overexpression Lysate (Native) - NBL1-08023 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BRCC3 Overexpression Lysate (Denatured) - H00079184-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human BRCC3 Knockdown Stable Cell Line - CSC-DC001524 from Creative biogene Category Cell Line Species Human

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