BRCC3

Gene Symbol BRCC3
Entrez Gene 79184
Alt Symbol BRCC36, C6.1A, CXorf53
Species Human
Gene Type protein-coding
Description BRCA1/BRCA2-containing complex, subunit 3
Other Description BRCA1-A complex subunit BRCC36|BRCA1/BRCA2-containing complex subunit 36|BRISC complex subunit BRCC36|lys-63-specific deubiquitinase BRCC36
Swissprots Q16107 A9Z1Y5 Q9BTZ6 B1B062 B4DQN7 A6QRF8 P46736 Q53YX5 A8MWH0 A6QRF9 A8MUX5 A9Z1Y0
Accessions EAW72632 EAW72633 EAW72634 EAW72635 EAW72636 EAW72637 P46736 AK298886 BAG60999 AK299194 BAG61237 AK310286 AK313544 BAG36320 AM392829 CAL37707 AY438030 AAR30498 BC002999 AAH02999 BC006540 AAH06540 BP304352 BU902387 S68015 AAB29005 X64643 CAA45917 XM_005274751 XP_005274808 NM_001018055 NP_001018065 NM_001242640 NP_001229569 NM_024332 NP_077308
Function Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:1920
Subcellular Location Nucleus {ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. {ECO:0000269|PubMed:16707425}.

BRCC3 (S-13) - sc-131122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-BRCC36 antibody - ab62075 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-BRCC36 antibody (ab62075) at 0.5 µg/mlLane 2 : Anti-BRCC36 antibody (ab62075) at 1 µg/mlLane 3 : Anti-BRCC36 antibody (ab62075) at 2 µg/mlLane 1 : MCF7 cell lysateLane 2 : MCF7 cell lysateLane 3 : MCF7 cell lysateLysates/proteins at 10 µg per lane.Secondaryanti-rabbit IgGObserved band size : 36 kDa (why is the actual band size different from the predicted?)

Anti-BRCC36 antibody [AT3B1] - ab104608 from Abcam

Prices $384.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT3B1
Anti-BRCC36 antibody [AT3B1] (ab104608) at 1/1000 dilution + HeLa cell lysate at 20 µgSecondaryGoat anti-mouse HRP conjugatedeveloped using the ECL technique

Anti-BRCC36 antibody [EPR4365] - ab108295 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4365
All lanes : Anti-BRCC36 antibody [EPR4365] (ab108295) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : SKBR3 cell lysateLane 3 : 293T cell lysateLane 4 : Human fetal kidney lysateLane 5 : HeLa cell lysateLysates/proteins at 10 µg per lane.

Anti-BRCC36 antibody [EPR4366] - ab108411 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4366
All lanes : Anti-BRCC36 antibody [EPR4366] (ab108411) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : MCF7 cell lysateLane 3 : SKBR-3 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-BRCC3 / BRCC36 Antibody (clone AT3B1) IHC-plus™ - LS-B3588 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT3B1
Anti-BRCC3 / BRCC36 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3588 concentration 5 ug/ml.

Anti-BRCC3 / BRCC36 Antibody (N-Terminus) IHC-plus™ - LS-B1339 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-BRCC3 / BRCC36 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1339 concentration 5 ug/ml.

Anti-BRCC3 / BRCC36 Antibody (N-Terminus) - LS-C56931 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BRCC3 / BRCC36 Antibody (aa1-316) - LS-C127107 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-BRCC3 / BRCC36 Antibody - LS-C306565 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-BRCC3 / BRCC36 Antibody (FITC) - LS-C317635 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BRCC3 / BRCC36 Antibody (HRP) - LS-C317637 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BRCC3 / BRCC36 Antibody (C-Terminus) - LS-C145876 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BRCC3 / BRCC36 antibody LS-C145876 Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.

Anti-BRCC3 / BRCC36 Antibody (C-Terminus) - LS-C145877 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BRCC3 / BRCC36 antibody LS-C145877 Western blot of 435S Cell lysate. Antibody concentration 1 ug/ml.

Anti-BRCC3 / BRCC36 Antibody (Biotin) - LS-C317638 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BRCC3 / BRCC36 Antibody (Internal, clone EPR4365) - LS-C138022 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4365
Western blot analysis on (A) MCF-7, (B) SKBR-3, (C) 293T, (D) fetal kidney, and (E) HeLa cell lysates using anti-BRCC36 antibody.

Anti-BRCC3 / BRCC36 Antibody - LS-C317636 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Lys-63-specific deubiquitinase BRCC36 antibody at 2 ug/ml with HeLa whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 36 KDa. Observed band size: 36 KDa.

Anti-BRCC3 / BRCC36 Antibody (aa266-316) - LS-C286921 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human BRCC36 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-BRCC36 used at a dilution of 1:250.

Anti-BRCC3 / BRCC36 Antibody (aa266-316) - LS-C289251 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human BRCC36 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-BRCC36 used at a dilution of 1:1000 (1 ug/ml).

Anti-BRCC3 / BRCC36 Antibody (Internal, clone EPR4366) - LS-C138211 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4366
Western blot analysis on (A) HeLa, (B) MCF-7, (C) SKBR-3, and (D) 293T cell lysates using anti-BRCC36 antibody.

BRCC3 Antibody - NBP1-76831 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: BRCC3 Antibody [NBP1-76831] - Analysis of BRCC36 in MCF7 cell lysate with BRCC36 antibody at (A) 0.5 and (B) 1 ug/mL.

BRCC3 Antibody - NBP1-03113 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: BRCC3 Antibody [NBP1-03113] - Staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

BRCC3 Antibody - NBP2-15609 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BRCC3 Antibody [NBP2-15609] - Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE gel, diluted at 1:5000.

BRCC3 Antibody (3B1) - NBP1-30429 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B1
Western Blot: BRCC3 Antibody (3B1) [NBP1-30429] - The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BRCC36 (1:1000). Proteins were visualized using a goat ant imouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: HeLa cell lysate Lane 2.: HepG2 cell lysate Lane 3.: 293T cell lysate Lane 4.: MCF7 cell lysate Lane 5.: NIH3T3 cell lysate.

BRCC3 Antibody - H00079184-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
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