BRCC3

Gene Symbol	BRCC3
Entrez Gene	79184
Alt Symbol	BRCC36, C6.1A, CXorf53
Species	Human
Gene Type	protein-coding
Description	BRCA1/BRCA2-containing complex, subunit 3
Other Description	BRCA1-A complex subunit BRCC36|BRCA1/BRCA2-containing complex subunit 36|BRISC complex subunit BRCC36|lys-63-specific deubiquitinase BRCC36
Swissprots	Q16107 A9Z1Y5 Q9BTZ6 B1B062 B4DQN7 A6QRF8 P46736 Q53YX5 A8MWH0 A6QRF9 A8MUX5 A9Z1Y0
Accessions	EAW72632 EAW72633 EAW72634 EAW72635 EAW72636 EAW72637 P46736 AK298886 BAG60999 AK299194 BAG61237 AK310286 AK313544 BAG36320 AM392829 CAL37707 AY438030 AAR30498 BC002999 AAH02999 BC006540 AAH06540 BP304352 BU902387 S68015 AAB29005 X64643 CAA45917 XM_005274751 XP_005274808 NM_001018055 NP_001018065 NM_001242640 NP_001229569 NM_024332 NP_077308
Function	Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:1920
Subcellular Location	Nucleus {ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. {ECO:0000269|PubMed:16707425}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BRCC36 full length protein - ab153507 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BRCC3 / BRCC36 Antibody Blocking Peptide - LS-E22638 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BRCC3 / BRCC36 Antibody Blocking Peptide - LS-E22637 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BRCC3 / BRCC36 Antibody Blocking Peptide - LS-E30390 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human BRCC3 Protein - H00079184-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BRCC3 Blocking Peptide - NBP1-76831PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Human BRCC3 protein - orb244051 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

BRCC3 - H00079184-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

BRCC3 - H00079184-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BRCC3 Control Peptide - AP30164CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

BRCC36 Peptide - 4331P from ProSci Category Peptide Species Human

BRCC3 fusion protein - ag7578 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

BRCC3 fusion protein - ag7584 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human BRCC3, His-tagged - BRCC3-10280H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) - RPN348Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) - RPN348Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Lys-63-specific deubiquitinase BRCC36(BRCC3) - CSB-YP002798HU CSB-BP002798HU CSB-MP002798HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human Lys-63-specific deubiquitinase BRCC36 - CSB-EP002798HU from Cusabio Category Protein Source E.coli Species Human

BRCC3 Protein - abx164510 from Abbexa Category Protein Species Human, Mouse, Rat

BRCC3-Blocking-Peptide-N-Term - BP21820a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BRCC3-Blocking-Peptide-N-Term - BP21929a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BRCC3 Peptide, Human - M34GP01524H from Creative Peptides Category Peptide Source Synthetic. Species Human

BRCC3 Recombinant Protein (OPCA01487) - OPCA01487 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Human BRCC3 protein - orb54043 from Biorbyt Category Protein Prices $213.00, $408.00, $612.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

Human BRCC3 protein - orb54200 from Biorbyt Category Protein Prices $213.00, $408.00, $612.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

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