BRCC3

Gene Symbol BRCC3
Entrez Gene 79184
Alt Symbol BRCC36, C6.1A, CXorf53
Species Human
Gene Type protein-coding
Description BRCA1/BRCA2-containing complex, subunit 3
Other Description BRCA1-A complex subunit BRCC36|BRCA1/BRCA2-containing complex subunit 36|BRISC complex subunit BRCC36|lys-63-specific deubiquitinase BRCC36
Swissprots Q16107 A9Z1Y5 Q9BTZ6 B1B062 B4DQN7 A6QRF8 P46736 Q53YX5 A8MWH0 A6QRF9 A8MUX5 A9Z1Y0
Accessions EAW72632 EAW72633 EAW72634 EAW72635 EAW72636 EAW72637 P46736 AK298886 BAG60999 AK299194 BAG61237 AK310286 AK313544 BAG36320 AM392829 CAL37707 AY438030 AAR30498 BC002999 AAH02999 BC006540 AAH06540 BP304352 BU902387 S68015 AAB29005 X64643 CAA45917 XM_005274751 XP_005274808 NM_001018055 NP_001018065 NM_001242640 NP_001229569 NM_024332 NP_077308
Function Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:1920
Subcellular Location Nucleus {ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. {ECO:0000269|PubMed:16707425}.

BRCC3 siRNA (h) - sc-90932 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRCC3 shRNA Plasmid (h) - sc-90932-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRCC3 shRNA (h) Lentiviral Particles - sc-90932-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRCC3 CRISPR/Cas9 KO Plasmid (h) - sc-407685 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCC3 HDR Plasmid (h) - sc-407685-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCC3 Double Nickase Plasmid (h) - sc-407685-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCC3 Double Nickase Plasmid (h2) - sc-407685-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCC3 CRISPR Activation Plasmid (h) - sc-407685-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCC3 CRISPR Activation Plasmid (h2) - sc-407685-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCC3 Lentiviral Activation Particles (h) - sc-407685-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCC3 Lentiviral Activation Particles (h2) - sc-407685-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEPDC1B siRNA (h) - sc-91972 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DEPDC1B shRNA Plasmid (h) - sc-91972-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DEPDC1B shRNA (h) Lentiviral Particles - sc-91972-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU069041 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4046 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4046 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10654 from Sigma-Aldrich

Category miRNA

BRCC3 siRNA (Human) - CRJ2353 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BRCC3 - MBS828095 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BRCC3 (NM_024332.3) - SHH247570 from Creative biogene

Category siRNA
Species Reactivities Human

Human BRCC3 siRNA - orb272854 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BRCC3 shRNA Plasmid (Human) - CHJ2353 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BRCC3 miRNA 3'UTR clone - MiUTR3H-02873 from Creative biogene

Species Reactivities Human

BRCC3 miRNA 3'UTR clone - MiUTR3H-02874 from Creative biogene

Species Reactivities Human
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