LDLRAP1

Gene Symbol	LDLRAP1
Entrez Gene	26119
Alt Symbol	ARH, ARH1, ARH2, FHCB1, FHCB2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor adaptor protein 1
Other Description	LDL receptor adaptor protein|autosomal recessive hypercholesterolemia protein|low density lipoprotein receptor adapter protein 1
Swissprots	Q6TQS9 Q9UFI9 A2BHI5 Q8N2Y0 Q5SW96
Accessions	AAQ90407 EAX07872 EAX07873 EAX07874 EAX07875 Q5SW96 AK024397 BAB14908 AK091219 BAG52309 AK124554 AK309850 AK309853 AL117654 CAB56030 BC029770 AAH29770 DA930479 HG491793 XM_006710559 XP_006710622 XM_006710560 XP_006710623 XM_006710561 XP_006710624 XM_011541209 XP_011539511 XM_011541210 XP_011539512 XM_011541211 XP_011539513 XM_011541212 XP_011539514 XR_426598 XR_946602 XR_946603 NM_015627 NP_056442
Function	Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. {ECO:0000269|PubMed:15728179}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12451172}.
Tissue Specificity	Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse ARH / LDLRAP1 ELISA Kit (Sandwich ELISA) - LS-F8685 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.067 ng/ml Range 0.156-10 ng/ml

Low density lipoprotein receptor adapter protein 1 (LDLRAP1), Human, ELISA Kit - CSB-EL012850HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

low density lipoprotein receptor adaptor protein 1, ELISA Kit - MBS920562 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 4.68 pg/ml Range 18.75 pg/ml-1200 pg/ml

Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1), ELISA Kit - MBS2024095 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse LDLRAP1 is typically less than 0.067ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL

ELISA Kit for Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) - SED104Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.067ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Low density lipoprotein receptor adapter protein 1(LDLRAP1) ELISA kit - CSB-EL012850HU from Cusabio Category ELISA Kit Sensitivity 4.68 pg/ml Range 18.75 pg/ml-1200 pg/ml

ELISA Kit for ADP Ribosylarginine Hydrolase (ADPRH) - SEJ672Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human LDLRAP1 ELISA Kit - E022967 from Biobool Category ELISA Kit Sensitivity 4.68 pg/ml

LDLRAP1 ELISA Kit (Human) (OKCA00714) - OKCA00714 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 4.68 pg/mL Range 18.75 pg/mL-1,200 pg/mL

anti-ARH / LDL receptor adaptor antibody - ARG63337 from Arigo Biolaboratories Category ELISA Kit

Human [Protein ADP-ribosylarginine] hydrolase (ADPRH) ELISA Kit - AE24050HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1), ELISA Kit - MBS9373448 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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