LDLRAP1

Gene Symbol	LDLRAP1
Entrez Gene	26119
Alt Symbol	ARH, ARH1, ARH2, FHCB1, FHCB2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor adaptor protein 1
Other Description	LDL receptor adaptor protein|autosomal recessive hypercholesterolemia protein|low density lipoprotein receptor adapter protein 1
Swissprots	Q6TQS9 Q9UFI9 A2BHI5 Q8N2Y0 Q5SW96
Accessions	AAQ90407 EAX07872 EAX07873 EAX07874 EAX07875 Q5SW96 AK024397 BAB14908 AK091219 BAG52309 AK124554 AK309850 AK309853 AL117654 CAB56030 BC029770 AAH29770 DA930479 HG491793 XM_006710559 XP_006710622 XM_006710560 XP_006710623 XM_006710561 XP_006710624 XM_011541209 XP_011539511 XM_011541210 XP_011539512 XM_011541211 XP_011539513 XM_011541212 XP_011539514 XR_426598 XR_946602 XR_946603 NM_015627 NP_056442
Function	Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. {ECO:0000269|PubMed:15728179}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12451172}.
Tissue Specificity	Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LDLRAP1 Lysate (Non-Denatured) - L019T6 from Acris Antibodies Category Cell Lysate Prices $290.00 Sizes 100 µg

LDLRAP1 293 Cell Lysate - 406950 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ARH Overexpression Lysate (Native) - NBL1-12478 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ARH (h): 293T Lysate - sc-114378 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

LDLRAP1 Over-expression Lysate Product - GWB-87C320 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human LDLRAP1 Knockdown Stable Cell Line - CSC-DC008622 from Creative biogene Category Cell Line Species Human

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