LDLRAP1

Gene Symbol	LDLRAP1
Entrez Gene	26119
Alt Symbol	ARH, ARH1, ARH2, FHCB1, FHCB2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor adaptor protein 1
Other Description	LDL receptor adaptor protein|autosomal recessive hypercholesterolemia protein|low density lipoprotein receptor adapter protein 1
Swissprots	Q6TQS9 Q9UFI9 A2BHI5 Q8N2Y0 Q5SW96
Accessions	AAQ90407 EAX07872 EAX07873 EAX07874 EAX07875 Q5SW96 AK024397 BAB14908 AK091219 BAG52309 AK124554 AK309850 AK309853 AL117654 CAB56030 BC029770 AAH29770 DA930479 HG491793 XM_006710559 XP_006710622 XM_006710560 XP_006710623 XM_006710561 XP_006710624 XM_011541209 XP_011539511 XM_011541210 XP_011539512 XM_011541211 XP_011539513 XM_011541212 XP_011539514 XR_426598 XR_946602 XR_946603 NM_015627 NP_056442
Function	Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. {ECO:0000269|PubMed:15728179}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12451172}.
Tissue Specificity	Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ARH full length protein - ab123174 from Abcam Category Protein Prices $402.00 Sizes 100 µg Source E. coli Species Human

Human ARH peptide - ab98261 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human ARH peptide - ab23072 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

ARH / LDLRAP1 Antibody Blocking Peptide - LS-E25566 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARH / LDLRAP1 Antibody Blocking Peptide - LS-E9425 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARH / LDLRAP1 Antibody Blocking Peptide - LS-E9426 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARH Recombinant Protein - H00026119-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ARH Protein - NBP1-78895 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

ARH Peptide - P2988 from Novus Biologicals Category Peptide Species Human

ARH Peptide - P2987 from Novus Biologicals Category Peptide Species Human

ARH-LDLRAP1-Antibody-C-term-Blocking-peptide - BP8013b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARH-LDLRAP1-Antibody-N-term-Blocking-peptide - BP8013a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARH blocking peptide - GTX25082-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human LDLRAP1 protein - orb168719 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

ADPRH protein (His tag) - 80R-2376 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

LDLRAP1 Blocking Peptide - 33R-10023 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LDLRAP1 protein (His tag) - 80R-2138 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

ARH Peptide - AC21-0395-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LDLRAP1 (1-308, His-tag) - AR50221PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

LDLRAP1 (1-308, His-tag) - AR50221PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

LDLRAP1 - H00026119-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LDLRAP1 - H00026119-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LDLRAP1, 1-308aa, Human, His tag, E.coli - 01-P1396 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

LDLRAP1 Peptide - 45-082P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

LDLRAP1 fusion protein - Ag4006 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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