LDLRAP1
| Gene Symbol | LDLRAP1 |
|---|---|
| Entrez Gene | 26119 |
| Alt Symbol | ARH, ARH1, ARH2, FHCB1, FHCB2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | low density lipoprotein receptor adaptor protein 1 |
| Other Description | LDL receptor adaptor protein|autosomal recessive hypercholesterolemia protein|low density lipoprotein receptor adapter protein 1 |
| Swissprots | Q6TQS9 Q9UFI9 A2BHI5 Q8N2Y0 Q5SW96 |
| Accessions | AAQ90407 EAX07872 EAX07873 EAX07874 EAX07875 Q5SW96 AK024397 BAB14908 AK091219 BAG52309 AK124554 AK309850 AK309853 AL117654 CAB56030 BC029770 AAH29770 DA930479 HG491793 XM_006710559 XP_006710622 XM_006710560 XP_006710623 XM_006710561 XP_006710624 XM_011541209 XP_011539511 XM_011541210 XP_011539512 XM_011541211 XP_011539513 XM_011541212 XP_011539514 XR_426598 XR_946602 XR_946603 NM_015627 NP_056442 |
| Function | Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. {ECO:0000269|PubMed:15728179}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12451172}. |
| Tissue Specificity | Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes. |
| Top Pathways | Endocytosis |
ARH CRISPR/Cas9 KO Plasmid (h) - sc-406114 from Santa Cruz Biotechnology
|
||||||||
ARH HDR Plasmid (h) - sc-406114-HDR from Santa Cruz Biotechnology
|
||||||||
ARH Double Nickase Plasmid (h) - sc-406114-NIC from Santa Cruz Biotechnology
|
||||||||
ARH Double Nickase Plasmid (h2) - sc-406114-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ARH CRISPR Activation Plasmid (h) - sc-406114-ACT from Santa Cruz Biotechnology
|
||||||||
ARH CRISPR Activation Plasmid (h2) - sc-406114-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ARH Lentiviral Activation Particles (h) - sc-406114-LAC from Santa Cruz Biotechnology
|
||||||||
ARH Lentiviral Activation Particles (h2) - sc-406114-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ARH siRNA (h) - sc-106784 from Santa Cruz Biotechnology
|
||||||||
ARH shRNA Plasmid (h) - sc-106784-SH from Santa Cruz Biotechnology
|
||||||||
ARH shRNA (h) Lentiviral Particles - sc-106784-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU048641 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN11629 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11629 from Sigma-Aldrich
|
||||||||
LDLRAP1 siRNA (Human) - CRH8717 from Cohesion Biosciences
|
||||||||
ARH RNAi - H00026119-R02 from Novus Biologicals
|
||||||||
ARH CRISPR/Cas9 KO Plasmid (h2) - sc-406114-KO-2 from Santa Cruz Biotechnology
|
||||||||
ARH HDR Plasmid (h2) - sc-406114-HDR-2 from Santa Cruz Biotechnology
|
||||||||
shRNA set against Human LDLRAP1 (NM_015627.2) - SHH329383 from Creative biogene
|
||||||||
shRNA set against Human LDLRAP1(NM_015627.2) - SHH145649 from Creative biogene
|
||||||||
Human LDLRAP1 siRNA - orb269219 from Biorbyt
|
||||||||
LDLRAP1 shRNA Plasmid (Human) - CHH8717 from Cohesion Biosciences
|
||||||||
LDLRAP1 miRNA 3'UTR clone - MiUTR1H-05625 from Creative biogene
|