SNF8

Gene Symbol	SNF8
Entrez Gene	11267
Alt Symbol	Dot3, EAP30, VPS22
Species	Human
Gene Type	protein-coding
Description	SNF8, ESCRT-II complex subunit
Other Description	EAP30 subunit of ELL complex|ELL-associated protein of 30 kDa|ESCRT-II complex subunit VPS22|SNF8, ESCRT-II complex subunit, homolog|hVps22|vacuolar-sorting protein SNF8
Swissprots	Q96H20 Q9UN50 Q8IXY3
Accessions	EAW94698 EAW94699 EAW94700 Q96H20 AF156102 AAD46560 AK123127 BC008976 AAH08976 BC038830 AAH38830 HQ447340 ADQ31826 XR_934359 NM_007241 NP_009172
Function	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. {ECO:0000269|PubMed:17714434, ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739}.
Subcellular Location	Cytoplasm. Endosome membrane. Nucleus {ECO:0000305}. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EAP30 (C-11) - sc-390747 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EAP30 (G-8) - sc-514147 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EAP30 (H-3) - sc-390748 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EAP30 (D-19) - sc-68972 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EAP30 (FL-258) - sc-366930 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EAP30 (N-16) - sc-68974 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EAP30 (LN-7) - sc-100892 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-EAP30 antibody - ab22768 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EAP30 antibody - ab84166 from Abcam Host Sheep Clonality Polyclonal

Anti-EAP30 antibody - ab56954 from Abcam Host Mouse Clonality Monoclonal

Anti-EAP30 antibody - ab56077 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (N-Terminus) IHC-plus™ - LS-B4561 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa23-123, clone 10C32, Azide-free) - LS-C183582 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 10C32

Anti-SNF8 / EAP30 Antibody (aa36-65, AP) - LS-C269782 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa36-65, APC) - LS-C269783 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa36-65, Biotin) - LS-C269784 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa36-65, FITC) - LS-C269785 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa36-65, Azide-free, HRP) - LS-C269786 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa36-65, PE) - LS-C269788 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (C-Terminus) - LS-C82006 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa36-65) - LS-C325230 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa179-228) - LS-C116763 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa25-74) - LS-C145435 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (aa37-65) - LS-C159049 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNF8 / EAP30 Antibody (N-Terminus) - LS-C47036 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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