| Gene Symbol |
SNF8
|
| Entrez Gene |
11267
|
| Alt Symbol |
Dot3, EAP30, VPS22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SNF8, ESCRT-II complex subunit
|
| Other Description |
EAP30 subunit of ELL complex|ELL-associated protein of 30 kDa|ESCRT-II complex subunit VPS22|SNF8, ESCRT-II complex subunit, homolog|hVps22|vacuolar-sorting protein SNF8
|
| Swissprots |
Q96H20 Q9UN50 Q8IXY3
|
| Accessions |
EAW94698 EAW94699 EAW94700 Q96H20 AF156102 AAD46560 AK123127 BC008976 AAH08976 BC038830 AAH38830 HQ447340 ADQ31826 XR_934359 NM_007241 NP_009172
|
| Function |
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. {ECO:0000269|PubMed:17714434, ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739}.
|
| Subcellular Location |
Cytoplasm. Endosome membrane. Nucleus {ECO:0000305}. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.
|
| Top Pathways |
Endocytosis
|