SNF8

Gene Symbol	SNF8
Entrez Gene	11267
Alt Symbol	Dot3, EAP30, VPS22
Species	Human
Gene Type	protein-coding
Description	SNF8, ESCRT-II complex subunit
Other Description	EAP30 subunit of ELL complex|ELL-associated protein of 30 kDa|ESCRT-II complex subunit VPS22|SNF8, ESCRT-II complex subunit, homolog|hVps22|vacuolar-sorting protein SNF8
Swissprots	Q96H20 Q9UN50 Q8IXY3
Accessions	EAW94698 EAW94699 EAW94700 Q96H20 AF156102 AAD46560 AK123127 BC008976 AAH08976 BC038830 AAH38830 HQ447340 ADQ31826 XR_934359 NM_007241 NP_009172
Function	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. {ECO:0000269|PubMed:17714434, ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739}.
Subcellular Location	Cytoplasm. Endosome membrane. Nucleus {ECO:0000305}. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EAP30 CRISPR/Cas9 KO Plasmid (h) - sc-406312 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 HDR Plasmid (h) - sc-406312-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 Double Nickase Plasmid (h) - sc-406312-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 Double Nickase Plasmid (h2) - sc-406312-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 CRISPR Activation Plasmid (h) - sc-406312-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 CRISPR Activation Plasmid (h2) - sc-406312-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 Lentiviral Activation Particles (h) - sc-406312-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 Lentiviral Activation Particles (h2) - sc-406312-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 siRNA (h) - sc-77279 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EAP30 shRNA Plasmid (h) - sc-77279-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EAP30 shRNA (h) Lentiviral Particles - sc-77279-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU008451 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19866 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19866 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03737 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03737

SNF8 siRNA (Human) - CRH7724 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SNF8 RNAi - H00011267-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

SNF8 - MBS8234973 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EAP30 CRISPR/Cas9 KO Plasmid (h2) - sc-406312-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EAP30 HDR Plasmid (h2) - sc-406312-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human SNF8 (NM_007241.2) - SHH414064 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SNF8(NM_007241.2) - SHL021634 from Creative biogene Category siRNA Species Reactivities Human

SNF8 shRNA Plasmid (Human) - CHH7724 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SNF8 miRNA 3'UTR clone - MiUTR1H-09691 from Creative biogene Species Reactivities Human

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