SNF8

Gene Symbol SNF8
Entrez Gene 11267
Alt Symbol Dot3, EAP30, VPS22
Species Human
Gene Type protein-coding
Description SNF8, ESCRT-II complex subunit
Other Description EAP30 subunit of ELL complex|ELL-associated protein of 30 kDa|ESCRT-II complex subunit VPS22|SNF8, ESCRT-II complex subunit, homolog|hVps22|vacuolar-sorting protein SNF8
Swissprots Q96H20 Q9UN50 Q8IXY3
Accessions EAW94698 EAW94699 EAW94700 Q96H20 AF156102 AAD46560 AK123127 BC008976 AAH08976 BC038830 AAH38830 HQ447340 ADQ31826 XR_934359 NM_007241 NP_009172
Function Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. {ECO:0000269|PubMed:17714434, ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739}.
Subcellular Location Cytoplasm. Endosome membrane. Nucleus {ECO:0000305}. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.
Top Pathways Endocytosis

Human-SNF8-cDNA-Clone - DC07209 from Abgent, a WuXi AppTec company

Prices $346.95
Sizes 10 µg
Species Human
Accession BC038830

SNF8 - MBS1274747 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC008976

SNF8 - MBS1278636 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC038830

Human SNF8 cDNA clone(NM_007241.2) - CDFH018239 from Creative Biomart

Species Human
Accession NM_007241.2

Human SNF8 cDNA clone(NM_007241.2) - CDFH018240 from Creative Biomart

Species Human
Accession NM_007241.2

human SNF8 ORF clone - CDCH083978 from Creative Biomart

Species Human
Accession NM_007241

human SNF8 ORF clone - CDCH083979 from Creative Biomart

Species Human
Accession NM_007241

Human SNF8 ORF Clone(NM_007241.2) - CDCL176516 from Creative Biomart

Species Human
Accession NM_007241.2

Human SNF8 ORF Clone(NM_007241.2) - CDCR294696 from Creative Biomart

Species Human
Accession NM_007241.2

Human SNF8 ORF Clone(NM_007241.2) - CDCR294697 from Creative Biomart

Species Human
Accession NM_007241.2

Human SNF8 ORF Clone(NM_007241.2) - CDCR294698 from Creative Biomart

Species Human
Accession NM_007241.2

Human SNF8 ORF Clone(NM_007241.2) - CDCR294696 from Creative biogene

Species Human

Human SNF8 ORF Clone (BC038830) - CDCS413132 from Creative biogene

Species Human
Accession Q96H20

Human SNF8 ORF Clone (BC008976) - CDCS413133 from Creative biogene

Species Human
Accession Q96H20

Human SNF8 cDNA Clone(NM_007241.2) - CDFH018239 from Creative biogene

Species Human

Human SNF8 cDNA Clone(NM_007241.2) - CDFH018240 from Creative biogene

Species Human
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