SNF8

Gene Symbol	SNF8
Entrez Gene	11267
Alt Symbol	Dot3, EAP30, VPS22
Species	Human
Gene Type	protein-coding
Description	SNF8, ESCRT-II complex subunit
Other Description	EAP30 subunit of ELL complex|ELL-associated protein of 30 kDa|ESCRT-II complex subunit VPS22|SNF8, ESCRT-II complex subunit, homolog|hVps22|vacuolar-sorting protein SNF8
Swissprots	Q96H20 Q9UN50 Q8IXY3
Accessions	EAW94698 EAW94699 EAW94700 Q96H20 AF156102 AAD46560 AK123127 BC008976 AAH08976 BC038830 AAH38830 HQ447340 ADQ31826 XR_934359 NM_007241 NP_009172
Function	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. {ECO:0000269|PubMed:17714434, ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739}.
Subcellular Location	Cytoplasm. Endosome membrane. Nucleus {ECO:0000305}. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EAP30 full length protein - ab128434 from Abcam Category Protein Source E. coli Species Human

SNF8 / EAP30 Antibody Blocking Peptide - LS-E5009 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNF8 / EAP30 Antibody Blocking Peptide - LS-E11567 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNF8 / EAP30 Antibody Blocking Peptide - LS-E11021 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNF8 / EAP30 Antibody Blocking Peptide - LS-E21192 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNF8 / EAP30 Antibody Blocking Peptide - LS-E21193 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNF8 Recombinant Protein - H00011267-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SNF8 Partial Recombinant Protein - H00011267-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SNF8 Protein - NBP1-98935 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

SNF8-Antibody-N-term-Blocking-Peptide - BP17410a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SNF8 protein - orb169314 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

EAP30 Blocking Peptide - 33R-6102 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Snf8 Blocking Peptide - 33R-3624 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SNF8 protein (His tag) - 80R-2334 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

Vacuolar-sorting protein SNF8 (1-258, His-tag) - AR50418PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

Vacuolar-sorting protein SNF8 (1-258, His-tag) - AR50418PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

Vacuolar-sorting protein SNF8 - H00011267-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Vacuolar-sorting protein SNF8 - H00011267-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Vacuolar-sorting protein SNF8 - H00011267-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Vacuolar-sorting protein SNF8 - H00011267-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SNF8, 1-258aa, Human, His tag, E.coli - 01-P1594 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

SNF8 fusion protein - Ag2606 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SNF8 Human - PRPS-1142 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human SNF8 Protein - BP002259-PRO-1135 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 20 µg, 1 mg Source E. coli-?derived. Species Human

SNF8, 1-258aa, Recombinant Protein - GWB-P0444B from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

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