| Gene Symbol |
PHOX2B
|
| Entrez Gene |
8929
|
| Alt Symbol |
NBLST2, NBPhox, PMX2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
paired-like homeobox 2b
|
| Other Description |
PHOX2B homeodomain protein|neuroblastoma Phox|neuroblastoma paired-type homeobox protein|paired mesoderm homeobox 2b|paired mesoderm homeobox protein 2B
|
| Swissprots |
Q99453 Q6PJD9
|
| Accessions |
AAD26698 BAA82670 EAW92989 Q99453 AI266171 BC017199 AAH17199 D82344 BAA11555 NM_003924 NP_003915
|
| Function |
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|
| Tissue Specificity |
Expressed in neuroblastoma, brain and adrenal gland.
|