| Gene Symbol |
CPLX1
|
| Entrez Gene |
10815
|
| Alt Symbol |
CPX-I, CPX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
complexin 1
|
| Other Description |
CPX I|complexin I|complexin-1|synaphin 2|synaphin-2
|
| Swissprots |
A6NI80 B2R4R5 F1T0G1 O14810 D3DVN3
|
| Accessions |
EAW82647 EAW82648 EAW82649 O14810 AB593095 BAJ84035 AF022383 AAB72108 AK126578 AK311921 BAG34862 BC002471 AAH02471 BT007029 AAP35676 KJ534815 AHW56455 XM_011513391 XP_011511693 NM_006651 NP_006642
|
| Function |
Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
|
| Tissue Specificity |
Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:15526345, ECO:0000269|PubMed:9853440}.
|
| Top Pathways |
Synaptic vesicle cycle
|
![Western Blot: Complexin-1 Overexpression Lysate (Adult Normal) [NBL1-09435] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Complexin-1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8363_Complexin-1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09435-img0002.jpg)