CPLX1

Gene Symbol CPLX1
Entrez Gene 10815
Alt Symbol CPX-I, CPX1
Species Human
Gene Type protein-coding
Description complexin 1
Other Description CPX I|complexin I|complexin-1|synaphin 2|synaphin-2
Swissprots A6NI80 B2R4R5 F1T0G1 O14810 D3DVN3
Accessions EAW82647 EAW82648 EAW82649 O14810 AB593095 BAJ84035 AF022383 AAB72108 AK126578 AK311921 BAG34862 BC002471 AAH02471 BT007029 AAP35676 KJ534815 AHW56455 XM_011513391 XP_011511693 NM_006651 NP_006642
Function Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
Tissue Specificity Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:15526345, ECO:0000269|PubMed:9853440}.
Top Pathways Synaptic vesicle cycle

Complexin-1 CRISPR/Cas9 KO Plasmid (h) - sc-406107 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-1 HDR Plasmid (h) - sc-406107-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-1 Double Nickase Plasmid (h) - sc-406107-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-1 Double Nickase Plasmid (h2) - sc-406107-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-1 CRISPR Activation Plasmid (h) - sc-406107-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-1 CRISPR Activation Plasmid (h2) - sc-406107-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-1 Lentiviral Activation Particles (h) - sc-406107-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-1 Lentiviral Activation Particles (h2) - sc-406107-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-1 siRNA (h) - sc-41923 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Complexin-1 shRNA Plasmid (h) - sc-41923-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Complexin-1 shRNA (h) Lentiviral Particles - sc-41923-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN6503 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6503 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CPLX1 siRNA (Human) - CRH7373 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CPLX1 - MBS8216603 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CPLX1 shRNA Plasmid (Human) - CHH7373 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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