CPLX1

Gene Symbol	CPLX1
Entrez Gene	10815
Alt Symbol	CPX-I, CPX1
Species	Human
Gene Type	protein-coding
Description	complexin 1
Other Description	CPX I|complexin I|complexin-1|synaphin 2|synaphin-2
Swissprots	A6NI80 B2R4R5 F1T0G1 O14810 D3DVN3
Accessions	EAW82647 EAW82648 EAW82649 O14810 AB593095 BAJ84035 AF022383 AAB72108 AK126578 AK311921 BAG34862 BC002471 AAH02471 BT007029 AAP35676 KJ534815 AHW56455 XM_011513391 XP_011511693 NM_006651 NP_006642
Function	Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
Tissue Specificity	Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:15526345, ECO:0000269|PubMed:9853440}.
Top Pathways	Synaptic vesicle cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CPLX1 full length protein - ab79148 from Abcam Category Protein Source E. coli Species Human

Human CPLX1 full length protein - ab116466 from Abcam Category Protein Source E. coli Species Human

CPLX1 / Complexin 1 Antibody Blocking Peptide - LS-E10117 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Complexin-1 Recombinant Protein - H00010815-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human Complexin-1 Protein - NBC1-18349 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Source E. coli Species Human

CPLX1-Antibody-Center-Blocking-Peptide - BP9412c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CPLX1 Protein (OPPA02070) - OPPA02070 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human Complexin-1 protein - orb81045 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli

Complexin 1 protein (His tag) - 80R-1088 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

Complexin-1 (1-134, His-tag) - AR09105PU-L from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

Complexin-1 (1-134, His-tag) - AR09105PU-N from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

Complexin-1 - H00010815-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

Complexin-1, Human Recombinant - 228-10272-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human CPLX1 - 228-10272-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human CPLX1 - 228-10272-3 from RayBiotech Category Protein Prices $1,950.00 Sizes 3 µg Source Escherichia Coli. Species Human

Complexin1, 1-134aa, Human, His tagged, Recombinant, E.coli - 01-2035 from ARP American Research Products Category Protein Prices $139.00, $299.00, $639.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

CPLX1 fusion protein - Ag0387 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CPLX1 Human - PRPS-652 from NeoScientific Category Protein Prices $65.00, $169.00, $2,340.00 Sizes 10 µg, 50 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Complexin-1 Protein - BP001536-PRO-645 from Syd Labs Category Protein Prices $160.00, $1,800.00 Sizes 50 µg, 1 mg Source E. coli-derived. Species Human

Complexin1, 1-134aa, Recombinant Protein - GWB-P0232K from Genway Biotech Category Protein Prices $210.00, $630.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human CPLX1, His-tagged - CPLX1-27587TH from Creative Biomart Category Protein Source E. coli

Recombinant Human CPLX1, His-tagged - CPLX1-27588TH from Creative Biomart Category Protein Source E. coli

Recombinant Human CPLX1, GST-tagged - CPLX1-11519H from Creative Biomart Category Protein Source E.coli Species Human

Complexin1 1-134aa - CXY -113 from Reagent Proteins Category Protein Prices $406.00, $700.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

CPLX1 Human - NKX-298 from Reagent Proteins Category Protein Prices $348.00, $2,047.00 Sizes 50.00 µg, 1 mg Source E.coli Species Human

Search more