CPLX1

Gene Symbol CPLX1
Entrez Gene 10815
Alt Symbol CPX-I, CPX1
Species Human
Gene Type protein-coding
Description complexin 1
Other Description CPX I|complexin I|complexin-1|synaphin 2|synaphin-2
Swissprots A6NI80 B2R4R5 F1T0G1 O14810 D3DVN3
Accessions EAW82647 EAW82648 EAW82649 O14810 AB593095 BAJ84035 AF022383 AAB72108 AK126578 AK311921 BAG34862 BC002471 AAH02471 BT007029 AAP35676 KJ534815 AHW56455 XM_011513391 XP_011511693 NM_006651 NP_006642
Function Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
Tissue Specificity Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:15526345, ECO:0000269|PubMed:9853440}.
Top Pathways Synaptic vesicle cycle

Complexin-1 Antibody - 13239 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cells lines and tissues using Complexin-1 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Complexin-1/2 Antibody - 13302 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines and tissues using Complexin-1/2 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Complexin-1 (E-17) - sc-14530 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CPLX1 antibody - ab15855 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-CPLX1 antibody (ab15855) at 1/2000 dilution + E.coli derived fusion protein.

Anti-CPLX1 antibody - ab102761 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab102761 at 1/50 dilution staining CPLX1 in Human brain tissue by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

Anti-CPLX1 / Complexin 1 Antibody (aa1-134) - LS-C79860 from LifeSpan Bioscience

Host Chicken
Clonality Polyclonal

Anti-CPLX1 / Complexin 1 Antibody (aa39-69, AP) - LS-C255331 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX1 / Complexin 1 Antibody (aa39-69, Azide-free, HRP) - LS-C255335 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX1 / Complexin 1 Antibody (aa39-69, APC) - LS-C255332 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX1 / Complexin 1 Antibody (aa39-69, Biotin) - LS-C255333 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX1 / Complexin 1 Antibody (aa39-69, FITC) - LS-C255334 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX1 / Complexin 1 Antibody (aa39-69, PE) - LS-C255336 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX1 / Complexin 1 Antibody (aa39-69) - LS-C320557 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX1 / Complexin 1 Antibody (aa39-69) - LS-C166990 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with CPLX1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Complexin-1/2 Antibody (837802) [Unconjugated] - MAB8069 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 837802
Western blot shows lysates of human brain (cerebellum) tissue, mouse brain (cortex) tissue, and rat brain (cerebellum) tissue. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human/Mouse/RatComplexin-1/2 Monoclonal Antibody (Catalog # MAB8069) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). Specific bands were detected for Complexin-1/2 at approximately 17-19 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Complexin-1/2 Antibody - AF7787 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human brain (hippocampus) tissue, mouse brain tissue, and rat brain (cerebellum) tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse/Rat Complexin-1/2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7787) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for Complexin-1/2 at approximately 17-19 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Complexin-1 Antibody - NB120-15855 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Western Blot: Complexin-1 Antibody [NB120-15855] - E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-CPLX1 )

CPLX1 Polyclonal Antibody - bs-11341R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded rat brain tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-CPLX1 Polyclonal Antibody, Unconjugated (bs-11341R) at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining

CPLX1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11341R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CPLX1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11341R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CPLX1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11341R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CPLX1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11341R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CPLX1 Polyclonal Antibody, Cy3 Conjugated - bs-11341R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CPLX1 Polyclonal Antibody, Cy5 Conjugated - bs-11341R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CPLX1 Polyclonal Antibody, Cy5.5 Conjugated - bs-11341R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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