| Gene Symbol | NEURL2 |
|---|---|
| Entrez Gene | 140825 |
| Alt Symbol | C20orf163, OZZ, OZZ-E3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | neuralized E3 ubiquitin protein ligase 2 |
| Other Description | neuralized homolog 2|neuralized-like protein 2 |
| Swissprots | Q3KR34 Q9BR09 |
| Accessions | EAW75790 Q9BR09 AJ295985 CAC82498 AK054821 BAB70810 AW298115 AW515245 BC074737 AAH74737 BC105935 AAI05936 BC107485 AAI07486 HY058356 NM_001278535 NP_001265464 NM_080749 NP_542787 |
| Function | Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Expressed specifically in skeletal and cardiac muscles. {ECO:0000269|PubMed:14960280}. |
neuralized homolog 2 (Drosophila) , ELISA Kit - MBS9324388 from MyBioSource
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Human NEURL2 ELISA Kit - E026055 from Biobool
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