| Gene Symbol |
NEURL2
|
| Entrez Gene |
140825
|
| Alt Symbol |
C20orf163, OZZ, OZZ-E3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuralized E3 ubiquitin protein ligase 2
|
| Other Description |
neuralized homolog 2|neuralized-like protein 2
|
| Swissprots |
Q3KR34 Q9BR09
|
| Accessions |
EAW75790 Q9BR09 AJ295985 CAC82498 AK054821 BAB70810 AW298115 AW515245 BC074737 AAH74737 BC105935 AAI05936 BC107485 AAI07486 HY058356 NM_001278535 NP_001265464 NM_080749 NP_542787
|
| Function |
Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed specifically in skeletal and cardiac muscles. {ECO:0000269|PubMed:14960280}.
|
![Western Blot: NEURL2 Overexpression Lysate (Adult Normal) [NBP2-05762] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NEURL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15007_NEURL2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05762-img0001.jpg)