Gene Symbol | NEURL2 |
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Entrez Gene | 140825 |
Alt Symbol | C20orf163, OZZ, OZZ-E3 |
Species | Human |
Gene Type | protein-coding |
Description | neuralized E3 ubiquitin protein ligase 2 |
Other Description | neuralized homolog 2|neuralized-like protein 2 |
Swissprots | Q3KR34 Q9BR09 |
Accessions | EAW75790 Q9BR09 AJ295985 CAC82498 AK054821 BAB70810 AW298115 AW515245 BC074737 AAH74737 BC105935 AAI05936 BC107485 AAI07486 HY058356 NM_001278535 NP_001265464 NM_080749 NP_542787 |
Function | Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed specifically in skeletal and cardiac muscles. {ECO:0000269|PubMed:14960280}. |
Neuralized-2 (A-11) - sc-398195 from Santa Cruz Biotechnology
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Neuralized-2 (H-68) - sc-368854 from Santa Cruz Biotechnology
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Neuralized-2 (J-24) - sc-133814 from Santa Cruz Biotechnology
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Neuralized-2 (N-13) - sc-98033 from Santa Cruz Biotechnology
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Anti-NEURL2 antibody - ab75159 from Abcam
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Anti-NEURL2 antibody - ab197251 from Abcam
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Anti-NEURL2 antibody - ab74266 from Abcam
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Anti-NEURL2 antibody - ab99125 from Abcam
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Anti-NEURL2 Antibody (N-Terminus) - LS-C82700 from LifeSpan Bioscience
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Anti-NEURL2 Antibody (aa143-192) - LS-C111408 from LifeSpan Bioscience
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NEURL2 Antibody - NBP2-13654 from Novus Biologicals
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Anti-NEURL2 antibody produced in rabbit - SAB4500483 from Sigma-Aldrich
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Anti-NEURL2 antibody produced in rabbit - SAB2105842 from Sigma-Aldrich
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Anti-NEURL2 antibody produced in rabbit - AV52524 from Sigma-Aldrich
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Anti-NEURL2 antibody produced in rabbit - HPA043402 from Sigma-Aldrich
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NEURL2 antibody - N-terminal region (ARP52524_P050) - ARP52524_P050 from Aviva Systems Biology
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NEURL2 antibody - middle region (ARP52525_P050) - ARP52525_P050 from Aviva Systems Biology
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NEURL2-Antibody - AP51385 from Abgent, a WuXi AppTec company
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Jagged 1 antibody - GTX10580 from GeneTex
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NEURL2 antibody - GTX87459 from GeneTex
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NEURL2 Antibody (OAAF03908) - OAAF03908 from Aviva Systems Biology
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NEURL2 antibody - 70R-18850 from Fitzgerald
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NEURL2 antibody - 70R-4136 from Fitzgerald
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NEURL2 antibody - 70R-5854 from Fitzgerald
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NEURL2 Antibody - abx007951 from Abbexa
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